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Series GSE199562 Query DataSets for GSE199562
Status Public on Sep 02, 2022
Title Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice [mouse]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We analyzed the expression profiles of human and mouse meningiomas (driven by NF2 loss, YAP1-MAML2, TRAF7/KLF4/SMO1/AKT1, or constitutively active non-fusion YAP1). We found that YAP1-MAML2 meningiomas resemble NF2mutant tumors and constitutively exert de-regulated YAP1 activity that is dependent on the interaction with TEADs.
 
Overall design Gene expression data from mouse RCAS-YAP1-MAML2-v2 or RCAS-NLS-2SA-YAP1-derived meningioma-like tumors (either extra-cranial, extra-axial, or intra-ventricular tumors).
 
Contributor(s) Szulzewsky F, Arora S, Holland EC
Citation(s) 36008139
Submission date Mar 28, 2022
Last update date Sep 11, 2022
Contact name Sonali Arora
E-mail(s) sarora@fredhutch.org
Organization name FHCRC
Street address 1100 Fairview Ave N,
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (10)
GSM5975223 mouse YAP1-MAML2-v2 rep1
GSM5975224 mouse YAP1-MAML2-v2 rep2
GSM5975225 mouse YAP1-MAML2-v2 rep3
This SubSeries is part of SuperSeries:
GSE199566 Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice
Relations
BioProject PRJNA820743

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE199562_RAW.tar 910.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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