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Series GSE200082 Query DataSets for GSE200082
Status Public on Apr 30, 2024
Title Acute social isolation alters synaptic plasticity in lateral habenula and social decision
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The lateral habenula (LHb) is an essential hub brain region modulating the monoamine system such as dopamine, serotonin. Hyperactivity of LHb has implications for psychiatric disorders such as depression, anxiety, and schizophrenia, which are commonly associated with social dysfunction. However, the role of LHb in social behavior has remained elusive. Here, we find that experiencing acute social isolation affects synaptic function in LHb and social behavior. After acute social isolation, long-term depression (LTD) in LHb is impaired and rescued by activating the 5-HT4 receptor (5-HT4R). Indeed, Htr4 expression in LHb is up-regulated following acute social isolation. Finally, acute social isolation enhances the social preference for familiars such as housing-mates to stranger conspecifics. Consistent with electrophysiological results, pharmacological activation of 5-HT4R in LHb restored innate social preference. These results suggest that acute social isolation influences social decisions with 5-HT4R-dependent synaptic modification in LHb.
Overall design The transcriptomic profiles of lateral habenula tissues obtained from group-housed and socially isolated mice
Contributor(s) Kim J, Chae S, Kang M
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Submission date Apr 03, 2022
Last update date Apr 30, 2024
Contact name Sehyun Chae
Organization name Korea Brain Research Institute
Department Neurovascular Unit Research Group
Street address 61, Cheomdan-ro, Dong-gu
City Daegu
ZIP/Postal code 41062
Country South Korea
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM6008387 Group-LHb-1
GSM6008388 Group-LHb-2
GSM6008389 iso-LHb-1
BioProject PRJNA822836

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE200082_RAW.tar 1000.0 Kb (http)(custom) TAR (of TXT)
GSE200082_Raw_counts_matrix.txt.gz 332.8 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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