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Series GSE200550 Query DataSets for GSE200550
Status Public on Apr 10, 2024
Title Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Cell therapy shows great promise as an alternative therapy for the cirrhotic liver. We have previously developed an approach for efficient expansion of both murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro without genetic modification. The current study aimed to apply HepLPCs to treatment of liver cirrhosis. The effects of allogeneic HepLPCs transplantation were studied in rat models of liver cirrhosis induced by carbon tetrachloride (CCl4) . Liver tissues were collected and analyzed by RNA sequencing array to analyze changes in histology or gene expression patterns. Transplantation of HepLPCs reduced active fibrogenesis and net fibrosis in model of liver cirrhosis. Apoptosis of hepatic stellate cells (HSCs) was observed in vivo after HepLPCs treatment.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for whole liver samples of control rats (normal) or rats injected with PBS or rat HepLPCs, n=3. Control livers were obtained from animals that received neither CCl4 nor cell transplants.
 
Contributor(s) Yan H, Zhou X
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Submission date Apr 10, 2022
Last update date Apr 10, 2024
Contact name hexin Yan
E-mail(s) yanhexin@renji.com
Phone 86-21-81875361
Organization name Shanghai Reji Hospital
Street address Pujian Road
City Shanghai
ZIP/Postal code 200120
Country China
 
Platforms (1)
GPL25947 Illumina NovaSeq 6000 (Rattus norvegicus)
Samples (9)
GSM6037614 Normal rat rep1
GSM6037615 Normal rat rep2
GSM6037616 Normal rat rep3
Relations
BioProject PRJNA825259

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE200550_RAW.tar 2.1 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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