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Series GSE20071 Query DataSets for GSE20071
Status Public on Apr 25, 2010
Title Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes (II)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of many examples, the transcription of non-coding RNA genes by RNA polymerase (pol) III is less well characterized. Here we profile the epigenetic features of pol III target genes throughout the human genome. This reveals that the chromatin landscape of pol III-transcribed genes resembles that of pol II templates in many ways, although there are also clear differences. Our analysis also discovered an entirely unexpected phenomenon, namely that pol II co-localizes with the majority of genomic loci that are bound by pol III.
Overall design RNA-seq experiment for total RNA in CD4+ cells.
Contributor(s) Barski A, Chepelev I, Birch J, Cuddapah S, Fleming A, Liko D, Cui K, White RJ, Zhao K
Citation(s) 20418881
Submission date Jan 27, 2010
Last update date May 15, 2019
Contact name Iouri Chepelev
Organization name US Department of Veterans Affairs Medical Center
Street address 3200 Vine St
City Cincinnati
State/province OH
ZIP/Postal code 45220
Country USA
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (1)
GSM501716 CD4_totalRNA_RNAseq
This SubSeries is part of SuperSeries:
GSE20072 Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
SRA SRP002105
BioProject PRJNA129797

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Supplementary file Size Download File type/resource
GSE20071_RAW.tar 436.9 Mb (http)(custom) TAR (of BED, GRAPH)
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Processed data provided as supplementary file
Raw data are available in SRA

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