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Series GSE202545 Query DataSets for GSE202545
Status Public on Nov 01, 2022
Title RNA-seq analysis of mouse esophageal tissue following GITR agonism in a model of esophageal squamous cell cancer
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Immune checkpoint modulation is an emerging therapeutic strategy for the treatment of esophageal squamous cell cancer (ESCC), but current strategies only benefit a fraction of patients. Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory immune checkpoint molecule that, upon engagement, can induce anti-tumor activity in solid tumor models. Here, we performed RNA sequencing analysis following targeting of GITR with an agonist antibody (clone DTA-1) or isotype control in the 4-nitroquinoline-1-oxide (4-NQO) mouse model of ESCC.
Overall design Total RNA was isolated from 4-NQO treated mice injected with either GITR agonist antibody (DTA-1) or isotype control. Murine esophageal tissue was peeled off and enriched enriched for invading cells Three replicates of each group were studied.
Contributor(s) Tetreault M, Wiles KN
Citation(s) 35880612
Submission date May 09, 2022
Last update date Feb 01, 2023
Contact name Marie-Pier Tetreault
Phone 312-503-1915
Organization name Northwestern University
Department Medicine/GI&Hep division
Lab Tarry 15-762
Street address 300 East Superior Street
City Chicago
State/province IL
ZIP/Postal code 60605
Country USA
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (6)
GSM6124225 4-NQO + isotype control rep1
GSM6124226 4-NQO + isotype control rep2
GSM6124227 4-NQO + isotype control rep3
BioProject PRJNA836540

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE202545_RAW.tar 1.1 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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