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Series GSE207102 Query DataSets for GSE207102
Status Public on Jul 15, 2022
Title Quercetin treatment lower Angiotensin-II-induced blood pressure
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The goals of this study is to compare the differently expressed genes in renal tissue of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the renal tissue of WT mice with AngII treatment with or without Quercetin (Que) treatment. The mice (n=18) were randomly divided into 3 groups: control, AngII,AngII+ Que (n=6 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and intragastrically with double distilled water (dd H2O); while mice in AngII + Que groups were infused with AngII (500 ng/kg/min) and intragastrically with 5mg/kg/D of Que for 4 weeks. Then the renal tissue were used to identify differentially expressed genes among different groups.
 
Overall design RNA sequencing was performed with renal tissue of mice in 3 groups: control, AngII, Quercetin treated (n=6 for each group) to identify the differently expressed genes and related pathway.
 
Contributor(s) Peng J, Shen A, Zhang X, Wen Y
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Submission date Jun 28, 2022
Last update date Jul 17, 2022
Contact name Jun Peng
E-mail(s) pjunlab@hotmail.com
Organization name Fujian University of Traditional Chinese Medicine
Department Academy of Integrative Medicine
Street address 1 Qiuyang Road, Minhou Shangjie
City Fuzhou
State/province Fujian
ZIP/Postal code 350122
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (18)
GSM6278532 Con_1
GSM6278533 Con_2
GSM6278534 Con_3
Relations
BioProject PRJNA853738

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE207102_RAW.tar 5.4 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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