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Series GSE207481 Query DataSets for GSE207481
Status Public on Sep 28, 2022
Title Macrophage-secreted CSF1 transmits a calorie restriction self-renewing signal to mammary epithelial stem cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Calorie restriction (CR) enhances stem cell self-renewal in various tissues, including the mammary gland. The hypothesis propelling this study states that similarly to their intestinal counterparts, mammary epithelial stem cells are insulated from sensing changes in the energy supply and, for that matter, depend on signals from a specific niche. Combined in vivo, in vitro and in silico studies identified macrophages and secreted CSF1 as the energy sensor and paracrine transmitter, respectively, of the CR inducing effect on mammary stem cell self-renewal.
Overall design The niche that transmits the calorie restriction (CR) self-renewing signal was identified by exposing stem cell cultures to conditioned medium collected from individual cell populations of CR and their ad libitum-fed counterparts. The signaling molecule was identified by RNA-Seq of the identified non-epithelial cell population. Conformation studies were then ensued.
Contributor(s) Kosenko A, Salame T, Friedlander G, Barash I
Citation(s) 36139499
Submission date Jul 05, 2022
Last update date Sep 28, 2022
Contact name Gilgi Friedlander
Organization name Weizmann Institute of Science
Street address Hertzel st
City Rehovot
ZIP/Postal code 76100
Country Israel
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (9)
GSM6288606 Control2
GSM6288607 Control3
GSM6288608 Control4
BioProject PRJNA855904

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Supplementary file Size Download File type/resource
GSE207481_processed_data.xlsx 720.1 Kb (ftp)(http) XLSX
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Processed data are available on Series record

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