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Status |
Public on Jun 07, 2023 |
Title |
Sex-based comparison of CD4+ T cell DNA methylation patterns in SLE reveals pro-inflammatory epigenetic changes in men |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
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Summary |
Male patients with systemic lupus erythematosus (SLE) experience severe disease compared to female patients, despite the disease being more prevalent in females. For the time, we compared genome-wide differential methylation in CD4+ T cells between male (n=12) and female (n=10) SLE patients.
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Overall design |
Illumina Infinium MethylationEPIC array of genomic DNA from CD4+ T cells extracted from peripheral blood mononuclear cells of 12 male SLE patients and 10 female SLE patients.
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Contributor(s) |
Ali M, Coit P, Sawalha AH |
Citation(s) |
36075396 |
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Submission date |
Jul 10, 2022 |
Last update date |
Jun 08, 2023 |
Contact name |
Amr H Sawalha |
E-mail(s) |
asawalha@pitt.edu
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Organization name |
University of Pittsburgh
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Street address |
4401 Penn Avenue
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City |
Pittsburgh |
State/province |
PA |
ZIP/Postal code |
15224 |
Country |
USA |
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Platforms (1) |
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Samples (22)
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Relations |
BioProject |
PRJNA857452 |