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Status |
Public on Nov 09, 2022 |
Title |
Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array SNP genotyping by SNP array
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Summary |
As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex population history. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. In addition, our analyses indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers.
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Overall design |
mtDNA data of 200 individuals from four Kazak populations in Jetisuu, Kazakstan were analyzed. 80 out of 200 samples were analyzed via GenoChip (Geno 2.0) microarray under the framework of Genographic Project, the Naional Geographic Society, USA.
>>>Raw data are not available for this series because the samples were genotyped via GenoChip under the framework of the Genographic Project, the National Geographic Society, USA. Submitter states that they do not have access to the raw data files<<<
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Contributor(s) |
Askapuli A, Vilar MG |
Citation(s) |
36445929 |
Submission date |
Jul 18, 2022 |
Last update date |
Feb 08, 2023 |
Contact name |
Ayken Askapuli |
E-mail(s) |
aykenau@gmail.com
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Organization name |
University of Wisconsin-Madison
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Department |
Integrative Biology
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Street address |
250 North Mills Street
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City |
Madison |
State/province |
WI |
ZIP/Postal code |
53706 |
Country |
USA |
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Platforms (1) |
GPL32489 |
mtDNA of GenoChip Microarray (Geno 2.0) |
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Samples (80)
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Relations |
BioProject |
PRJNA859815 |
Supplementary file |
Size |
Download |
File type/resource |
GSE208402_RAW.tar |
2.1 Mb |
(http)(custom) |
TAR (of TXT) |
GSE208402_matrix_of_genotypes_different_from_rCRS.xlsx |
146.6 Kb |
(ftp)(http) |
XLSX |
Processed data provided as supplementary file |
Processed data are available on Series record |
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