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Series GSE208402 Query DataSets for GSE208402
Status Public on Nov 09, 2022
Title Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex population history. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. In addition, our analyses indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers.
Overall design mtDNA data of 200 individuals from four Kazak populations in Jetisuu, Kazakstan were analyzed. 80 out of 200 samples were analyzed via GenoChip (Geno 2.0) microarray under the framework of Genographic Project, the Naional Geographic Society, USA.

>>>Raw data are not available for this series because the samples were genotyped via GenoChip under the framework of the Genographic Project, the National Geographic Society, USA. Submitter states that they do not have access to the raw data files<<<
Contributor(s) Askapuli A, Vilar MG
Citation(s) 36445929
Submission date Jul 18, 2022
Last update date Feb 08, 2023
Contact name Ayken Askapuli
Organization name University of Wisconsin-Madison
Department Integrative Biology
Street address 250 North Mills Street
City Madison
State/province WI
ZIP/Postal code 53706
Country USA
Platforms (1)
GPL32489 mtDNA of GenoChip Microarray (Geno 2.0)
Samples (80)
GSM6345678 AC37JTJ3CT
GSM6345679 ACD3LL4PN3
GSM6345680 ACK5Y36DVN
BioProject PRJNA859815

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE208402_RAW.tar 2.1 Mb (http)(custom) TAR (of TXT)
GSE208402_matrix_of_genotypes_different_from_rCRS.xlsx 146.6 Kb (ftp)(http) XLSX
Processed data provided as supplementary file
Processed data are available on Series record

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