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| Status |
Public on Jul 23, 2022 |
| Title |
Comparative analysis of the testis tissue transcriptome of 4-year-old yak and cattle-yak |
| Organisms |
Bos grunniens; Bos grunniens x Bos taurus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RNA sequence analysis identified a total of 8473 differentially expressed genes (DEGs) (3580 up-regulated, 4893 down-regulated), and GO annotation and KEGG enrichment of differential genes found that DEGS were mostly related to spermatogenesis and apoptosis. Among them, Spermatogonia stem cell (SSCs) marker genes (ITGA5, Gfra1, CD9, SOHLH1, SALL4, ID4 and FOXO1) were significantly up-regulated, differentiation spermatogenic cell marker genes (KIT, UCHL1, Ccna1, TNP1 and TXNDC2) were significantly down-regulated, and genes involved in apoptosis (Fas, CTSK, CTSB, CTSC, CTSO, caspase 3, caspase6, and caspase) were significantly up-regulated. Furthermore, the AS events in cattle-yak are significantly lower than in yak, we speculate that lack of mRNA and protein subtypes may lead to spermatogenic arrest in yak testicle.
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| Overall design |
RNA-seq of yak and cattle-yak testis tissue.
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| Contributor(s) |
Cao M, Guo X, Pei J |
| Citation(s) |
36230452 |
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| Submission date |
Jul 20, 2022 |
| Last update date |
Oct 28, 2022 |
| Contact name |
shaoke guo |
| E-mail(s) |
82101205332@caas.cn
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| Phone |
15036009308
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| Organization name |
Chinese Academy of Agricultural Sciences
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| Department |
Lanzhou institute of husbandry and pharmaceutical sciences
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| Street address |
West Lake Street
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| City |
Lanzhou |
| State/province |
Gansu |
| ZIP/Postal code |
730050 |
| Country |
China |
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| Platforms (2) |
| GPL22950 |
Illumina HiSeq 2500 (Bos grunniens) |
| GPL32499 |
Illumina HiSeq 2500 (Bos grunniens x Bos taurus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA860618 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208693_FPKM_anno.txt.gz |
2.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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