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| Status |
Public on Sep 22, 2023 |
| Title |
CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We engineered human models of CBFA2T3::GLIS2 acute megakaryoblastic leukemia and compared gene expression profiles to primary pediatric samples.
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| Overall design |
RNA sequencing of human models of CBFA2T3::GLIS2 and NUP98 rearranged acute megakaryoblastic leukemia. CD34+ cord blood hematopoietic stem/progenitor cells were used as control.
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| Contributor(s) |
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée V, Wilhelm BT, Cellot S |
| Citation(s) |
37729615 |
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| Submission date |
Jul 24, 2022 |
| Last update date |
Oct 26, 2023 |
| Contact name |
Sonia Cellot |
| E-mail(s) |
sonia.cellot@umontreal.ca
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| Phone |
(514) 345-4931 6026
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| Organization name |
Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center
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| Street address |
3175 Côte-Sainte-Catherine
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| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3T 1C5 |
| Country |
Canada |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA861854 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE209628_RAW.tar |
68.3 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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