NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE210011 Query DataSets for GSE210011
Status Public on Aug 07, 2023
Title Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-associated Immunity in Lynch Syndrome patients [GeoMx Digital Spatial Profiling (DSP)]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This CYCling Lynch patients for Exercise and Prevention (CYCLE-P) trial was a prospective, non-randomized controlled trial conducted at the Familial High-Risk Gastrointestinal and Cancer Prevention Clinic of The University of Texas MD Anderson Cancer Center. Twenty-one LS participants with a confirmed pathogenic mutation in one of four DNA mismatch repair (MMR) genes were enrolled between April 2018 and January 2019. Follow-up was conducted 1-year from the start of the intervention. Statistical analysis by both per-protocol and intention-to-treat was performed from March to May 2021.
 
Overall design CYCLE-P was a prospective, non-randomized controlled trial that enrolled 21 consecutive participants diagnosed with LS in a 12-month aerobic exercise intervention involving cycling classes in a local community (n=5) followed by enrollment of patients to usual care (n=3) between April 2018 to January 2019. All eligible participants provided written informed consent before enrollment, and the conduction of the trial complied with the Declaration of Helsinki. The trial protocol and all amendments were approved by the MD Anderson Cancer Center institutional review board. We followed the Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) reporting guidelines.
 
Contributor(s) Vilar-Sanchez E, Deng N
Citation(s) 37724990
NIH grant(s)
Grant ID Grant title Affiliation Name
P30 CA016672 Cancer Center Support Grant The University of Texas MD Anderson Cancer Center Peter W Pisters
P50 CA221707 MD Anderson Cancer Center SPORE in Gastrointestinal Cancer The University of Texas MD Anderson Cancer Center Scott Kopetz
Submission date Jul 28, 2022
Last update date Nov 06, 2023
Contact name Eduardo Vilar-Sanchez
Organization name The University of Texas MD Anderson Cancer Center
Street address 1515 Holcombe Blvd
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (54)
GSM6413443 Patient 17 Group: Control (End-of-Study) rep_1
GSM6413444 Patient 17 Group: Control (End-of-Study) rep_2
GSM6413445 Patient 17 Group: Control (End-of-Study) rep_3
Relations
BioProject PRJNA863309

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE210011_Hs_R_NGS_WTA_v1.0.pkc.gz 1.9 Mb (ftp)(http) PKC
GSE210011_RAW.tar 3.5 Mb (http)(custom) TAR (of DCC)
GSE210011_matrix.txt.gz 1.5 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap