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Series GSE211244 Query DataSets for GSE211244
Status Public on Aug 20, 2022
Title RNAseq Analysis of TP53+/+ and TP53-/- HCT116 colon carcinoma cell lines after treatment with p53 or ATF4-activating compounds
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We examined the gene expression changes resulting from treatment of either "wild-type" or "p53-deficient" human cell lines with compounds known to activate either p53 (nutlin-3A,etoposide) or the integrated stress response (ISR) transcription factor ATF4 (histidinol,tunicamycin)
 
Overall design Comparative gene expression profiling (polyA+ selected RNAseq) on three biological replicates
 
Contributor(s) Sammons M
Citation(s) 36993734
NIH grant(s)
Grant ID Grant title Affiliation Name
R35 GM138120 Defining cis-regulatory networks controlling a core stress response UNIVERSITY AT ALBANY, SUNY Morgan Andrew Sammons
Submission date Aug 15, 2022
Last update date May 29, 2023
Contact name Morgan A Sammons
E-mail(s) masammons@albany.edu
Organization name University at Albany - SUNY
Department Biological Sciences
Lab Sammons
Street address 1400 Washington Ave, Life Sciences 2075
City Albany
State/province NY
ZIP/Postal code 12222
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (30)
GSM6459598 WT_DMSO_2_RNAseq_DMSO, 6hrs_rep2
GSM6459599 WT_DMSO_3_RNAseq_DMSO, 6hrs_rep3
GSM6459600 WT_Nut_1_RNAseq_Nutlin 3A, 5 micromolar, 6hrs_rep1
Relations
BioProject PRJNA869674

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE211244_RAW.tar 77.9 Mb (http)(custom) TAR (of TSV)
GSE211244_deseq2_DMSO_vs_Etoposide_HCT116.tsv.gz 2.0 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Etoposide_HCT116_p53KO.tsv.gz 2.0 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Histidinol_HCT116.tsv.gz 1.9 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Histidinol_HCT116_p53KO.tsv.gz 1.9 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Nutlin_HCT116.tsv.gz 1.9 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Nutlin_HCT116_p53KO.tsv.gz 1.9 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Tunicamycin_HCT116.tsv.gz 2.0 Mb (ftp)(http) TSV
GSE211244_deseq2_DMSO_vs_Tunicamycin_HCT116_p53KO.tsv.gz 2.0 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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