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Series GSE2119 Query DataSets for GSE2119
Status Public on Dec 15, 2005
Title Global analysis of X chromosome dosage compensation
Organism Drosophila melanogaster
Experiment type Expression profiling by array
Summary We have conducted a global analysis of somatic dosage compensation and also asked if germ cell dosage compensate by microarray analysis of gene expression in wild-type tissues. To obviate the confounding effects of scatter and especially the skewed genomic distributions of genes with sex-biased expression in both the soma and germline [there are fewer X chromosome genes with male-biased expression], we used mutations that transform sexual identity. In the soma we used gain-of-function transformer to turn X;AA flies into somatic females with tumorous germlines. The gonadectomized somas of these X;AA female flies were compared to similarly prepared XX;AA females. The X;AA ovarian tumors, which are possibly the result of germline sex transformations, were compared to the similar XX;AA ovarian tumors generated with loss-of-function alleles of ovarian tumor and Sex-lethal. We used alleles of transformer-2 and doublesex to transform XX;AA flies into somatic males with atrophic germlines.
Keywords: other
Contributor(s) Gupta V, Parisi M, Sturgill D, Nuttall R, Doctolero M, Malley JD, Dudko OK, Eastman S, Oliver B
Citation(s) 16507155
Submission date Jan 03, 2005
Last update date Jan 18, 2013
Contact name Brian Oliver
Phone 301-204-9463
Organization name NIDDK, NIH
Department LBG
Lab Developmental Genomics
Street address 50 South Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL20 Incyte Drosophila LifeArray v1.0
Samples (27)
GSM37438 (X;AA) hs-tra carcass vs (XX;AA) pi[[2]]/ y w - 28
GSM37439 (X;AA) B[s]Y; hs-tra carcass vs (X;AA) Male Carcass - 29
GSM37440 (X;AA) B[s]Y; hs-tra carcass vs (XX;AA) Female Carcass - 34
BioProject PRJNA91723

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