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Series GSE212089 Query DataSets for GSE212089
Status Public on May 05, 2023
Title Meningeal natural killer cells and innate lymphoid cells 1 tune anxiety and memory via interferon-γ and acetylcholine
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The mechanisms of communication between the brain and the neighboring meningeal immune cells are still unclear. Here we characterized the resident group 1 innate lymphoid cells in the meninges of adult mice, and identified ILC1/NK cell-derived interferon- and acetylcholine as mediators involved in the modulation of brain circuitries underlying anxiety-like behavior and memory. This discloses a new meningeal-to-brain communication mechanism that modulates brain functions under physiological conditions.
 
Overall design To expand our understanding of functions of individual meningeal cell populations, we investigated group 1 innate lymphoid cells (ILCs), which comprise conventional NK1.1+ NK cells and type 1 ILCs in adult male mice by single-cell RNA-sequencing.
 
Contributor(s) Garofalo S, Limatola C, Laffranchi M, Sciumè G, Sozzani S, Mortari EP, Carsetti R
Citation(s) 37248289
Submission date Aug 26, 2022
Last update date Aug 04, 2023
Contact name Mattia Laffranchi
E-mail(s) mattia.laffranchi@uniroma1.it
Organization name La Sapienza University of Rome
Department Molecular Medicine
Street address Viale Regina Elena 291
City Rome
ZIP/Postal code 00161
Country Italy
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (1)
GSM6509111 scRNA_Mouse_ILC_Spleen and Meninges
Relations
BioProject PRJNA873941

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE212089_SampleTag01_mm_RSEC_MolsPerCell.csv.gz 4.2 Mb (ftp)(http) CSV
GSE212089_SampleTag02_mm_RSEC_MolsPerCell.csv.gz 2.6 Mb (ftp)(http) CSV
GSE212089_SampleTag03_mm_RSEC_MolsPerCell.csv.gz 2.3 Mb (ftp)(http) CSV
GSE212089_SampleTag04_mm_RSEC_MolsPerCell.csv.gz 2.6 Mb (ftp)(http) CSV
GSE212089_SampleTag07_mm_RSEC_MolsPerCell.csv.gz 2.9 Mb (ftp)(http) CSV
GSE212089_readme.txt 2.3 Kb (ftp)(http) TXT
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