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| Status |
Public on Mar 27, 2023 |
| Title |
Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To evaluate whether liver metabolic pathways are affected by non-hepatic cancer in-vivo, we performed RNA sequencing of hepatocytes isolated from perfused livers of WT and 4T1 breast cancer-bearing mice on days 4 and 21 following cancer cells injection.
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| Overall design |
At 2 time points, day 4 and day 21 following PBS or 4T1 BC cells injection, 3 mice from each group were sacrificed and their hepatocytes were sent for RNA Seq analysis.
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| Contributor(s) |
Omer G, Emma H, Ayelet E |
| Citation(s) |
36972357 |
| Submission date |
Aug 26, 2022 |
| Last update date |
Jun 26, 2023 |
| Contact name |
Ayelet Erez |
| E-mail(s) |
ayelet.erez@weizmann.ac.il
|
| Phone |
089343714
|
| Organization name |
WEIZMANN INSTITUTE
|
| Street address |
CANDIOTTI 214
|
| City |
Rehovot |
| State/province |
Please Select |
| ZIP/Postal code |
76100 |
| Country |
Israel |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA874037 |
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