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Series GSE212873 Query DataSets for GSE212873
Status Public on Dec 21, 2022
Title Fibroblast Growth Factor-2 bound to specific dermal fibroblasts-derived extracellular vesicles is protected from degradation: relevance to wound healing
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Fibroblast growth factor-2 (FGF2) has multiples roles in cutaneous wound healing but its natural low stability prevents the development of its use in therapeutic for impaired skin repair. Here we show that FGF2 binds the outer surface of dermal fibroblast (DF)-derived extracellular vesicles (EVs) and this association protects FGF2 from fast degradation. We performed RNA-seq analysis after EV treatment to examine modulated genes in DFs.
 
Overall design Twenty-four hours after stimulation with CTL-EVs or FGF2-EVs, RNA was extracted, amplified and sequencedand used for RNA-seq
 
Contributor(s) Qu J, Zhou H, Petit I
Citation(s) 36550142
Submission date Sep 07, 2022
Last update date Jan 11, 2023
Contact name Jo Huiqing Zhou
E-mail(s) jo.zhou@radboudumc.nl
Organization name Radboud University
Street address Geert Grooteplein 26/18
City Nijmegen
ZIP/Postal code 6525GA
Country Netherlands
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (16)
GSM6560183 aFGF-38-CTRL
GSM6560184 aFGF-38-ECTRL
GSM6560185 aFGF-38-EFGF
Relations
BioProject PRJNA877679

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE212873_RAW.tar 7.3 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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