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Series GSE212938 Query DataSets for GSE212938
Status Public on Sep 13, 2022
Title Comparative Study of the Expression Profiles of miRNAs of Milk-Derived Exosomes of Yak and Jeryak
Organisms Bos grunniens; Bos grunniens x Bos taurus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The Jeryak is the hybrid offspring of yaks and Jersey cattle and exhibit improved milk and meat yields. Biomolecules carried within milk exosomes are important for cell growth, development, immune regulation, and various pathophysiological processes. Previous studies showed that miRNAs regulate mammary gland development, lactation, and milk quality. This study explored the relationship between milk exosomes miRNAs and lactation performance. A comparison of the milk content showed that yak milk was of a better quality compared to Jeryak milk (casein, fat, TS, SNF, lactose). Milk collected in December was superior to that collected in June for both yak and Jeryak, except for lactose concentrations. Exosomes were extracted by density gradient centrifugation and miRNA expression profiles in milk exosomes from three yaks and three Jeryaks collected in June and December were detected by small RNA sequencing. In all, 22, 120, 78, and 62 differentially expressed miRNAs (DEMs) were identified in Jun_ JY vs. Jun_ Y (P1: Jeryak in June vs. Yak in June), Jun_ JY vs. Dec_ JY (P2: Jeryak in June vs. Jeryak in December), Dec_ JY vs. Dec_ Y (P3: Jeryak in December vs. Yak in December), and Jun_ Y vs. Dec_ Y (P4: Yak in June vs. Yak in December) groups. These DEMs were enriched in functions and signaling pathways related to lactation performance. In conclusion, these findings are a reference tool to study the molecular basis of lactation performance.
 
Overall design miRNA sequencing of milk exosomes of yak and Jeryak in June and December
 
Contributor(s) Ren W, Yan P, Liang C
Citation(s) 36428417
Submission date Sep 08, 2022
Last update date Dec 22, 2022
Contact name Xingdong Wang
E-mail(s) wxd17339929758@126.com
Phone 17339929758
Organization name CAAS: Chinese Academy of Agricultural Sciences
Street address No.335 Jiangouyan, Qilihe District
City Lanzhou
State/province 未选择
ZIP/Postal code 730050
Country China
 
Platforms (2)
GPL30409 Illumina NovaSeq 6000 (Bos grunniens)
GPL32644 Illumina NovaSeq 6000 (Bos grunniens x Bos taurus)
Samples (12)
GSM6564250 Dec, CY1
GSM6564251 Dec, CY2
GSM6564252 Dec, CY3
Relations
BioProject PRJNA878496

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE212938_Processed_data_files.xlsx 248.2 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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