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| Status |
Public on Nov 27, 2023 |
| Title |
Prolonged sleep deprivation induces cytokine storm-like syndrome in mammals [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Sleep is deeply involved in neuroimmune regulation, while the mechanism is yet to be elucidated. Experimental manipulation of sleep duration provides a reliable measure for evaluating how sleep regulates innate immunity. Here we report a modified sleep deprivation paradigm (SD) that can constantly awaken the mice with more than 95% efficiency, and investigate the effects of prolonged sleep deprivation on mice's immune systems.
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| Overall design |
Blood leukocytes were isolated from the mice under control (Con), sleep deprivation(SD), or a previously reported sleep restriction method (SASD) condition after different time points to investigate the transcriptome alteration
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| Contributor(s) |
Lin K, Sang D, Zhang E |
| Citation(s) |
38016470 |
| |
| Submission date |
Sep 16, 2022 |
| Last update date |
Nov 30, 2023 |
| Contact name |
Erquan Zhang |
| E-mail(s) |
zhangerquan@nibs.ac.cn
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| Organization name |
National Institute of Biological Sciences, Beijing
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| Lab |
ErquanZhang
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| Street address |
7 Science Park Road, ZGC Life Science Park
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| City |
Beijing |
| ZIP/Postal code |
102206 |
| Country |
China |
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| Platforms (1) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE213497 |
Prolonged sleep deprivation induces cytokine storm-like syndrome in mammals |
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| Relations |
| BioProject |
PRJNA881226 |
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