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Series GSE214268 Query DataSets for GSE214268
Status Public on Jun 09, 2023
Title RAGE Inhibitor TTP488 (Azeliragon) Reduces Metastasis in Triple-Negative Breast Cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We tested the preclinical efficacy of two small molecule RAGE inhibitors (TTP488 (Azeliragon) and FPS-ZM1) against TNBC metastasis in the orthotopic xenograft MDA-MB-231/4175 - NSG model. Both TTP488 and FPS-ZM1 impaired TNBC metastasis in this lung metastatic breast cancer model, with TTP488 affecting metastasis to a greater degree than FPS-ZM1. Transcriptomic analysis of the primary tumors revealed that TTP488 and FPS-ZM1 displayed high concordance in gene expression changes affecting metastatic pathways.
Overall design Comparison of gene expression changes in RAGE inhibitor treated primary tumor tissues and vehicle (DMSO) treated tumors.
Web link
Contributor(s) Hudson B, McIntosh A, Magna M
Citation(s) 37443146
Submission date Sep 27, 2022
Last update date Oct 17, 2023
Contact name Barry I Hudson
Organization name Georgetown University
Department Oncology
Lab Hudson lab
Street address 3970 Reservoir Road,
City NW Washington
State/province District of Columbia
ZIP/Postal code 20007
Country USA
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (6)
GSM6602828 NSG15.D1.T
GSM6602829 NSG15.D2.T
GSM6602830 NSG15.FPS1.T
BioProject PRJNA884681

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE214268_Filtered_Count_Table.txt.gz 236.6 Kb (ftp)(http) TXT
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Processed data are available on Series record

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