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| Status |
Public on Dec 01, 2022 |
| Title |
Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The objective of this study is to identify immunological mechanisms that contribute to normalization of liver inflammation in chronic hepatitis B (CHB) patients starting the antiviral nucleoside analogue, Tenofovir alafenamide (TAF).
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| Overall design |
Investigator-initiated, phase 4 study in which recruited patients received TAF 25mg once daily for 48 weeks. The total duration of the study to End of Follow-up was 48 weeks. After Week 48, participants were offered 2 years of TAF therapy. Sample collection 0, 12, 24 w was chosen to analyze immune responses based on ALT normalization rates. This mono-center study was conducted at Toronto Centre for Liver Disease, Canada.
***Raw data for human samples not available due to patient privacy concerns***
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| Contributor(s) |
Nkongolo S, Mahamed D, Kuipery A, Sanchez Vasquez JD, Kim SC, Mehrotra A, Patel A, Hu C, McGilvray I, Feld JJ, Fung S, Chen D, Wallin JJ, Gaggar A, Janssen HL, Gehring AJ |
| Citation(s) |
36594467 |
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| Submission date |
Oct 21, 2022 |
| Last update date |
May 16, 2023 |
| Contact name |
Adam Gehring |
| E-mail(s) |
adam.gehring@uhnresearch.ca
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| Organization name |
UHN
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| Street address |
101 College St
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| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (15)
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| GSM6668687 |
liver, patient8, week0 |
| GSM6668688 |
liver, patient8, week12 |
| GSM6668689 |
liver, patient8, week24 |
| GSM6668690 |
liver, patient9, week0 |
| GSM6668691 |
liver, patient9, week12 |
| GSM6668692 |
liver, patient9, week24 |
| GSM6668693 |
liver, patient10, week0 |
| GSM6668694 |
liver, patient10, week12 |
| GSM6668695 |
liver, patient10, week24 |
| GSM6668696 |
liver, patient11, week0 |
| GSM6668697 |
liver, patient11, week12 |
| GSM6668698 |
liver, patient11, week24 |
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| Relations |
| BioProject |
PRJNA892977 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE216314_Metadata.txt.gz |
234.5 Kb |
(ftp)(http) |
TXT |
| GSE216314_barcodes.tsv.gz |
222.3 Kb |
(ftp)(http) |
TSV |
| GSE216314_features.tsv.gz |
310.8 Kb |
(ftp)(http) |
TSV |
| GSE216314_matrix.mtx.gz |
222.6 Mb |
(ftp)(http) |
MTX |
| Raw data not provided for this record |
| Processed data are available on Series record |
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