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Series GSE217861 Query DataSets for GSE217861
Status Public on Nov 15, 2022
Title Immunoediting instructs tumor metabolic reprogramming to support immune evasion [TCR-seq]
Organism Mus musculus
Experiment type Other
Summary Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early staged tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by a non-canonical IFNg-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells for empowering them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.
Overall design Examination of CD8 T cell receptor répertoire in tumor-infiltrating lymphocytes from tumor with or without early T cell depletion
Contributor(s) Tsai C, Ho P
Citation(s) 36599297
Submission date Nov 12, 2022
Last update date Feb 14, 2023
Contact name Ping-Chih Ho
Organization name Ludwig Cancer Institute, UNIL
Street address Ch. des Boveresses 155
City Epalinges
ZIP/Postal code 1066
Country Switzerland
Platforms (1)
GPL32159 NextSeq 1000 (Mus musculus)
Samples (7)
GSM6729123 TCR-seq_C1
GSM6729124 TCR-seq_C2
GSM6729125 TCR-seq_C3
This SubSeries is part of SuperSeries:
GSE217482 Immunoediting instructs tumor metabolic reprogramming to support immune evasion
BioProject PRJNA901032

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE217861_RAW.tar 720.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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