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Series GSE217861 Query DataSets for GSE217861
Status Public on Nov 15, 2022
Title Immunoediting instructs tumor metabolic reprogramming to support immune evasion [TCR-seq]
Organism Mus musculus
Experiment type Other
Summary Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early staged tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by a non-canonical IFNg-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells for empowering them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.
 
Overall design Examination of CD8 T cell receptor répertoire in tumor-infiltrating lymphocytes from tumor with or without early T cell depletion
 
Contributor(s) Tsai C, Ho P
Citation(s) 36599297
Submission date Nov 12, 2022
Last update date Feb 14, 2023
Contact name Ping-Chih Ho
Organization name Ludwig Cancer Institute, UNIL
Street address Ch. des Boveresses 155
City Epalinges
ZIP/Postal code 1066
Country Switzerland
 
Platforms (1)
GPL32159 NextSeq 1000 (Mus musculus)
Samples (7)
GSM6729123 TCR-seq_C1
GSM6729124 TCR-seq_C2
GSM6729125 TCR-seq_C3
This SubSeries is part of SuperSeries:
GSE217482 Immunoediting instructs tumor metabolic reprogramming to support immune evasion
Relations
BioProject PRJNA901032

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE217861_RAW.tar 720.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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