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Series GSE221196 Query DataSets for GSE221196
Status Public on Oct 02, 2023
Title Temporal scRNAseq of metastasizing tumor cells and lung endothelial cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary During metastasis, cancer cells travel the circulation to colonise distant sites. Due to the rarity of these events, the immediate cell fate decisions of metastasising tumour cells (mTC) are poorly understood and the role of the endothelium, as dissemination interface, remains elusive. Using a novel combinatorial mTC enrichment approach, we provide a first transcriptional blueprint of the early colonisation process
Overall design Mice were intravenously injected with tumor cells. Lung endothelial cells and distinct tumor cell subpopulations were isolated 1.5 days and 3.5 days post-injection, respectively. Uninjected leftover tumor cells and lung endothelial cells from uninjected mice served as baseline controls.
Contributor(s) Jakab M, Augustin HG
Citation(s) 38308117
Submission date Dec 16, 2022
Last update date Feb 05, 2024
Contact name Moritz Jakab
Organization name German Cancer Research Center
Street address Im Neuenheimer Feld
City Heidelberg
ZIP/Postal code 69221
Country Germany
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (5375)
GSM6850291 day 0 - replicate 1 AS-367775-LR-45389
GSM6850292 day 0 - replicate 1 AS-367777-LR-45389
GSM6850293 day 0 - replicate 1 AS-367779-LR-45389
This SubSeries is part of SuperSeries:
GSE221202 Transcriptional blueprint of the early colonisation process
BioProject PRJNA913176

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE221196_E0_15995.csv.gz 2.5 Mb (ftp)(http) CSV
GSE221196_E0_15996.csv.gz 2.6 Mb (ftp)(http) CSV
GSE221196_E0_15997.csv.gz 2.3 Mb (ftp)(http) CSV
GSE221196_E1.5_15998.csv.gz 2.9 Mb (ftp)(http) CSV
GSE221196_E1.5_15999.csv.gz 2.6 Mb (ftp)(http) CSV
GSE221196_E1.5_16000.csv.gz 3.2 Mb (ftp)(http) CSV
GSE221196_E3.5_16001.csv.gz 2.5 Mb (ftp)(http) CSV
GSE221196_E3.5_16002.csv.gz 2.4 Mb (ftp)(http) CSV
GSE221196_E3.5_16003.csv.gz 2.6 Mb (ftp)(http) CSV
GSE221196_EC_filtered_normalised.csv.gz 32.8 Mb (ftp)(http) CSV
GSE221196_T0_culture_16004.csv.gz 4.5 Mb (ftp)(http) CSV
GSE221196_T1.5_extra_16006.csv.gz 4.7 Mb (ftp)(http) CSV
GSE221196_T1.5_intra_16005.csv.gz 5.0 Mb (ftp)(http) CSV
GSE221196_T3.5_dorm_16007.csv.gz 5.0 Mb (ftp)(http) CSV
GSE221196_T3.5_prol_16008.csv.gz 4.4 Mb (ftp)(http) CSV
GSE221196_TC_filtered_normalised.csv.gz 50.7 Mb (ftp)(http) CSV
GSE221196_annotation_EC.csv.gz 8.4 Kb (ftp)(http) CSV
GSE221196_annotation_TC.csv.gz 4.9 Kb (ftp)(http) CSV
GSE221196_capEC_filtered_normalised.csv.gz 49.9 Mb (ftp)(http) CSV
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