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Series GSE221200 Query DataSets for GSE221200
Status Public on Oct 02, 2023
Title Assessment of the dormant and proliferative vascular metastatic niche
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary During metastasis, cancer cells travel the circulation to colonise distant sites. Due to the rarity of these events, the immediate cell fate decisions of metastasising tumour cells (mTC) are poorly understood and the role of the endothelium, as dissemination interface, remains elusive. Using a novel combinatorial mTC enrichment approach, we provide a first transcriptional blueprint of the early colonisation process
Overall design Mice were injected with niche-labeling dormant (D20R) or proliferative (4T1) breast cancer cell lines and labeled, as well as matched unlabeled lung endothelial cells were sampled 3.5 days post-injection. Comparative gene expression profiling analysis of RNAseq data for lung endothelial cells from the different conditions.
Contributor(s) Jakab M, Augustin HG
Citation(s) 38308117
Submission date Dec 16, 2022
Last update date Jun 12, 2024
Contact name Moritz Jakab
Organization name German Cancer Research Center
Street address Im Neuenheimer Feld
City Heidelberg
ZIP/Postal code 69221
Country Germany
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (36)
GSM6855688 PBS treated total EC - replicate 1
GSM6855689 PBS treated total EC - replicate 2
GSM6855690 PBS treated total EC - replicate 3
This SubSeries is part of SuperSeries:
GSE221202 Transcriptional blueprint of the early colonisation process
BioProject PRJNA913178

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Supplementary file Size Download File type/resource
GSE221200_NicheSeq_annotation_sheet.xlsx 9.6 Kb (ftp)(http) XLSX
GSE221200_NicheSeq_count_matrix_annotated.txt.gz 1.3 Mb (ftp)(http) TXT
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