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Series GSE221459 Query DataSets for GSE221459
Status Public on Jun 15, 2024
Title Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We identified novel nicotinamide-based FLT3 inhibitors ( HSN748) that specifically target FLT3-ITD at sub-nanomolar concentrations and are effective against drug-resistant secondary mutations. In the current study, we evaluated these compounds’ antileukemic activity against FLT3-ITD and gatekeeper mutations in drug-resistant AML, relapsed/refractory AMLs with FLT3 mutations
 
Overall design We performed gene expression profiling analysis using data obtained from RNA-seq data from MOLM14 cells
Comparative gene expression profiling analysis of RNA-seq data for MOLM14 cells treated with DMSO and HSN748
 
Contributor(s) Ramdas B, Kapur R, Liu S, Wan J
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 20, 2022
Last update date Jun 15, 2024
Contact name Baskar Ramdas
E-mail(s) ramdasb@iu.edu
Organization name Indiana University
Department Wells Center for Pediatric Research
Lab Reuben Kapur
Street address 1044 West Walnut Street
City Indianapolis
State/province Indiana
ZIP/Postal code 46202
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM6870650 RB1-MOLM14.DMSO
GSM6870651 RB2-MOLM14.DMSO
GSM6870652 RB3-MOLM14.DMSO
Relations
BioProject PRJNA914332

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE221459_mRNAseq_M_DMSO_M_HSN748.xlsx 6.7 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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