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Series GSE221459 Query DataSets for GSE221459
Status Public on Jun 15, 2024
Title Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We identified novel nicotinamide-based FLT3 inhibitors ( HSN748) that specifically target FLT3-ITD at sub-nanomolar concentrations and are effective against drug-resistant secondary mutations. In the current study, we evaluated these compounds’ antileukemic activity against FLT3-ITD and gatekeeper mutations in drug-resistant AML, relapsed/refractory AMLs with FLT3 mutations
Overall design We performed gene expression profiling analysis using data obtained from RNA-seq data from MOLM14 cells
Comparative gene expression profiling analysis of RNA-seq data for MOLM14 cells treated with DMSO and HSN748
Contributor(s) Ramdas B, Kapur R, Liu S, Wan J
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Submission date Dec 20, 2022
Last update date Jun 15, 2024
Contact name Baskar Ramdas
Organization name Indiana University
Department Wells Center for Pediatric Research
Lab Reuben Kapur
Street address 1044 West Walnut Street
City Indianapolis
State/province Indiana
ZIP/Postal code 46202
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM6870650 RB1-MOLM14.DMSO
GSM6870651 RB2-MOLM14.DMSO
GSM6870652 RB3-MOLM14.DMSO
BioProject PRJNA914332

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE221459_mRNAseq_M_DMSO_M_HSN748.xlsx 6.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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