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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 31, 2023 |
| Title |
Comprehensive analysis of the transcriptome-wide m6A methylation in mouse neural stem cells after hypoxia/reoxygenation |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
Ischemia-reperfusion injury to the central nervous system (CNS) often causes severe complications. Hypoxia/reoxygenation (H/R) is one of the most common and detrimental internal environmental changes experienced by local cells and is often used to simulate the process of ischemia-reperfusion in vitro. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repair after injury. However, the specific biological processes and molecular mechanisms of NSC activation remain unclear, and the role of N6-methyladenosine (m6A) methylation modification in this process has not been explored.
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| Overall design |
MeRIP-seq was performed on NSCs of control group (n=3) and H/R group (n=3) respectively.
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| Contributor(s) |
Fang B, Zhang S, Li Y, Fan Y, Cui K |
| Citation(s) |
38360659 |
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| Submission date |
Dec 28, 2022 |
| Last update date |
Feb 26, 2024 |
| Contact name |
Bo Fang |
| E-mail(s) |
bfang@cmu.edu.cn
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| Organization name |
The First Hospital of China Medical University
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| Department |
Department of Anesthesiology
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| Street address |
NO.155, North Nanjing Street
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| City |
Shenyang |
| State/province |
Liaoning |
| ZIP/Postal code |
110001 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM6900555 |
NSC, control_IP, rep1 |
| GSM6900556 |
NSC, control_IP, rep2 |
| GSM6900557 |
NSC, control_IP, rep3 |
| GSM6900558 |
NSC, H/R_input, rep1 |
| GSM6900559 |
NSC, H/R_input, rep2 |
| GSM6900560 |
NSC, H/R_input, rep3 |
| GSM6900561 |
NSC, H/R_IP, rep1 |
| GSM6900562 |
NSC, H/R_IP, rep2 |
| GSM6900563 |
NSC, H/R_IP, rep3 |
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| Relations |
| BioProject |
PRJNA916478 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE221841_Methylated_RNA_sites.circRNA_Control-A.txt.gz |
49.0 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.circRNA_Control-B.txt.gz |
38.1 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.circRNA_Control-C.txt.gz |
33.5 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.circRNA_HR-A.txt.gz |
70.8 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.circRNA_HR-B.txt.gz |
58.5 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.circRNA_HR-C.txt.gz |
82.8 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_Control-A.txt.gz |
146.1 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_Control-B.txt.gz |
104.6 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_Control-C.txt.gz |
95.8 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_HR-A.txt.gz |
247.5 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_HR-B.txt.gz |
182.5 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.lncRNA_HR-C.txt.gz |
301.1 Kb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_Control-A.txt.gz |
1.8 Mb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_Control-B.txt.gz |
1.4 Mb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_Control-C.txt.gz |
1.2 Mb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_HR-A.txt.gz |
2.4 Mb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_HR-B.txt.gz |
1.9 Mb |
(ftp)(http) |
TXT |
| GSE221841_Methylated_RNA_sites.mRNA_HR-C.txt.gz |
2.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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