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Series GSE223360 Query DataSets for GSE223360
Status Public on May 24, 2023
Title Circadian transcriptomic analysis of mouse liver during a time restricted feeding
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Determination, using microarrays, of the mouse hepatic global programme of gene expression variations around the clock when animals had food access restricted to the active periode (ZT12 to ZT24) after a 11 days training periode
The unique functional versatility of the liver is paramount for the organism homeostasis. Both liver development and adult life are controlled by tightly regulated transcription factor networks, among which nuclear receptors (NRs) regulate essential functions of parenchymal and nonparenchymal cells. Acting as transcription factors sensitive to extracellular cues such as steroidal hormones, lipid metabolites, xenobiotics… and modulated by intracellular signaling pathways, NRs orchestrate many aspects of hepatic physiology. While liver functional zonation and adaptability to fluctuating conditions are known to rely on a sophisticated cellular architecture, the exact functions of NRs in liver cell types remain poorly characterized. As a first step toward the accurate mapping of NR functions in mouse liver, we characterized their levels of expression in whole liver as a function of time and diet, and explored NRs isoform expression in hepatocytes, cholangiocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal cells. In addition, we leveraged liver single cell RNAseq studies to provide here an up-to-date compendium of NR expression in mouse liver in space and time.
 
Overall design All time points were analyzed in triplicats
 
Contributor(s) Berthier A, Gheeraert C, Vinod M, Lefebvre P
Citation(s) 36988391
Submission date Jan 20, 2023
Last update date May 25, 2023
Contact name Alexandre Berthier
E-mail(s) alexandre.berthier@inserm.fr
Phone 0320974217
Organization name Inserm
Street address U1011, Bâtiment J&K, Bd du Pr Leclerc
City Lille
ZIP/Postal code 59000
Country France
 
Platforms (1)
GPL18233 [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [probe set (exon) version]
Samples (36)
GSM6946090 Liver_ZT0_rep1
GSM6946091 Liver_ZT0_rep2
GSM6946092 Liver_ZT0_rep3
Relations
BioProject PRJNA925874

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE223360_RAW.tar 290.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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