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Series GSE225770 Query DataSets for GSE225770
Status Public on Aug 07, 2023
Title CD8+ cells and small viral reservoirs facilitate post-ART SIV control in MHC-M3+ Mauritian cynomolgus macaques
Organism Macaca fascicularis
Experiment type Expression profiling by high throughput sequencing
Summary Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority in the HIV field. We observed surprising PTC in an MHC-haplomatched cohort of SIVmac239+ Mauritian cynomolgus macaques (MCMs) initiated on ART at two weeks post-infection (wpi). For six months after ART withdrawal, we observed undetectable or transient viremia in seven of eight MCMs. In vivo CD8α depletion induced rebound in all animals, indicating the PTC was mediated by CD8α+ cells. We found that MCMs had a smaller acute viral reservoir than a cohort of identically infected rhesus macaques, a population that rarely develops PTC. The mechanisms by which unusually small viral reservoirs and CD8α+ cell-mediated virus suppression enable PTC can be investigated using this model of PTC in MHC-haplomatched MCMs. If the immunological mechanisms that can engender PTC are defined, this model could designate therapeutic targets for HIV remission strategies in humans. 
 
Overall design Comparative gene expression proifiling analysis of RNA-seq data for CD8+ T cells isolated from peripheral blood mononuclear cells (PBMCs) of SIV+ Mauritian Cynomolgus macaques.
 
Contributor(s) Harwood OE, Matschke LM, Moriarty RV, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Winchester LC, Fletcher CV, Friedrich TC, Keele BF, O’Connor DH, Lang JD, Reynolds MR, O’Connor SL
Citation(s) 36909458, 37747933
Submission date Feb 21, 2023
Last update date Oct 18, 2023
Contact name Shelby O'Connor
E-mail(s) slfeinberg@wisc.edu
Organization name University of Wisconsin-Madison
Street address 555 Science Drive
City Madison
State/province WI
ZIP/Postal code 53711
Country USA
 
Platforms (1)
GPL28212 Illumina NovaSeq 6000 (Macaca fascicularis)
Samples (16)
GSM7055989 cy0721_01_onART
GSM7055990 cy0721_02_postART
GSM7055991 cy0724_01_onART
Relations
BioProject PRJNA937379

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE225770_RAW.tar 34.1 Mb (http)(custom) TAR (of TXT)
GSE225770_salmon.merged.gene_counts.xlsx 1.8 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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