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| Status |
Public on Oct 03, 2023 |
| Title |
Role of TET1-mediated epigenetic modulation in Alzheimer’s disease [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the influence the partial loss of Tet1 has on AD pathogenesis in 5xFAD mice, we crossed a Tet1 KO mouse line with the 5xFAD mouse line to generate WT, 5xFAD, Tet1(+/-), and FAD/Tet1(+/-) mice.
We then performed gene expression profiling analysis using data obtained from RNA-seq from biological replicates of mice comprised of 4 different genotypes.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for WT, 5xFAD, Tet1(+/-), FAD/Tet1(+/-) mice to determine how the partial loss of Tet1 influences 5xFAD-associated gene expression and pathology.
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| Contributor(s) |
Armstrong MJ |
| Citation(s) |
37562656 |
| Submission date |
Feb 24, 2023 |
| Last update date |
Oct 04, 2023 |
| Contact name |
Matthew J Armstrong |
| E-mail(s) |
matthew.armstrong@emory.edu
|
| Organization name |
Emory University
|
| Street address |
615 Michael St
|
| City |
Atlanta |
| State/province |
Georgia |
| ZIP/Postal code |
30322 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE226056 |
Role of TET1-mediated epigenetic modulation in Alzheimer's disease |
|
| Relations |
| BioProject |
PRJNA938432 |
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