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Series GSE226053 Query DataSets for GSE226053
Status Public on Oct 03, 2023
Title Role of TET1-mediated epigenetic modulation in Alzheimer’s disease [RNA-Seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To investigate the influence the partial loss of Tet1 has on AD pathogenesis in 5xFAD mice, we crossed a Tet1 KO mouse line with the 5xFAD mouse line to generate WT, 5xFAD, Tet1(+/-), and FAD/Tet1(+/-) mice.
We then performed gene expression profiling analysis using data obtained from RNA-seq from biological replicates of mice comprised of 4 different genotypes.
Overall design Comparative gene expression profiling analysis of RNA-seq data for WT, 5xFAD, Tet1(+/-), FAD/Tet1(+/-) mice to determine how the partial loss of Tet1 influences 5xFAD-associated gene expression and pathology.
Contributor(s) Armstrong MJ
Citation(s) 37562656
Submission date Feb 24, 2023
Last update date Oct 04, 2023
Contact name Matthew J Armstrong
Organization name Emory University
Street address 615 Michael St
City Atlanta
State/province Georgia
ZIP/Postal code 30322
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM7062064 biol WT1
GSM7062065 biol WT2
GSM7062066 biol WT3
This SubSeries is part of SuperSeries:
GSE226056 Role of TET1-mediated epigenetic modulation in Alzheimer's disease
BioProject PRJNA938432

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE226053_RAW.tar 2.3 Mb (http)(custom) TAR (of TXT)
GSE226053_VST_normalized_counts.txt.gz 1.3 Mb (ftp)(http) TXT
GSE226053_padj_0.1_resFADTet1vsTet1.txt.gz 1.1 Mb (ftp)(http) TXT
GSE226053_padj_0.1_resFADvsFADTet1.txt.gz 1.0 Mb (ftp)(http) TXT
GSE226053_padj_0.1_resFADvsWT.txt.gz 1.1 Mb (ftp)(http) TXT
GSE226053_padj_0.1_resTet1vsFAD.txt.gz 998.9 Kb (ftp)(http) TXT
GSE226053_padj_0.1_resTet1vsWT.txt.gz 1.1 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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