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Series GSE226193 Query DataSets for GSE226193
Status Public on Nov 15, 2023
Title Microarray expression analysis depicting MHCII-dependent features of FOXP3-expressing CD4 T regulatory cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis comparing K14 and MCHII+/- Tregs. The hypothesis was that the lack of MHCII+/- in the spleen and intestine would result in a large shift in K14 Treg gene expression away from an activated and effector phenotype. Results demonstrate how a lack of MHCII-antigen presentation in the small intestine, where Tregs exhibit an effector penotype, does not greatly reduce effector features of T regulatory cells in K14 mice.
 
Overall design RNA was isolated from splenic and intestinal FOXP3 Tregs and conventional T cells from control MHCII+/-, FOXP3GFP mice and experimental K14Aβb, FOXP3GFP mice which lack expression of MHCII outside of the thymus. Mice were pooled for each condition.
 
Contributor(s) Korn LL, Beiting D, Laufer TM
Citation(s) 36935092
Submission date Feb 27, 2023
Last update date Feb 14, 2024
Contact name Terri Laufer
E-mail(s) tlaufer@pennmedicine.upenn.edu
Phone (215)573-2955
Organization name University of Pennsylvania
Lab 276 John Morgan Building
Street address 3620 Hamilton Walk
City Philadlephia
State/province Pennsylvania
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM7067670 Splenic T conventional cells rep1
GSM7067671 Splenic T regulatory cells rep1
GSM7067672 Splenic T conventional cells rep2
Relations
BioProject PRJNA939149

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE226193_RAW.tar 3.1 Mb (http)(custom) TAR
GSE226193_non-normalized.txt.gz 975.4 Kb (ftp)(http) TXT
Processed data included within Sample table

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