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| Status |
Public on Oct 02, 2023 |
| Title |
Gene expression profile at single nuclei level of brain tissues from diabetic mice exposed to acute or recurrent hypoglycemia. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
The brain is an important controller of glucose homeostasis and mediates counterregulatory responses to hypoglycemia. We used single-nuclei transcriptomics to study the mechanisms of defective hypoglycaemia counter-regulation in brain in a model of diabetic mice exposed to acute or recurrent hypoglycemia.
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| Overall design |
Single nuclei were isolated from hypothalamus and cortex tissues of diabetic mice subjected to recurrent (RH) or acute hypoglycemia (AH) and used to generate transcriptome profiles.
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| Contributor(s) |
Castillo Armengol J, Marzetta F, Rodriguez Sanchez-Archidona A, Thorens B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 28, 2023 |
| Last update date |
Oct 03, 2023 |
| Contact name |
Flavia Marzetta |
| E-mail(s) |
flavia.marzetta@sib.swiss
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| Organization name |
Swiss Institute of Bioinformatics
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| Street address |
Quartier Sorge - Batiment Genopode
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| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
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| Platforms (2) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (14)
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| GSM7070456 |
Hypothalamus RH, replicate 1, Multiome (RNA) |
| GSM7070457 |
Hypothalamus AH, replicate 1, Multiome (RNA) |
| GSM7070458 |
Hypothalamus RH, replicate 2, Multiome (RNA) |
| GSM7070459 |
Hypothalamus AH, replicate 2, Multiome (RNA) |
| GSM7070460 |
Cortex RH, replicate 1, Multiome (RNA) |
| GSM7070461 |
Cortex AH, replicate 1, Multiome (RNA) |
| GSM7070462 |
Cortex RH, replicate 2, RNA |
| GSM7070463 |
Cortex AH, replicate 2, RNA |
| GSM7070464 |
Hypothalamus RH, replicate 1, Multiome (ATAC) |
| GSM7070465 |
Hypothalamus AH, replicate 1, Multiome (ATAC) |
| GSM7070466 |
Hypothalamus RH, replicate 2, Multiome (ATAC) |
| GSM7070467 |
Hypothalamus AH, replicate 2, Multiome (ATAC) |
| GSM7070468 |
Cortex RH, replicate 1, Multiome (ATAC) |
| GSM7070469 |
Cortex AH, replicate 1, Multiome (ATAC) |
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| Relations |
| BioProject |
PRJNA939516 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE226277_RAW.tar |
6.3 Gb |
(http)(custom) |
TAR (of H5, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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