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Series GSE226277 Query DataSets for GSE226277
Status Public on Oct 02, 2023
Title Gene expression profile at single nuclei level of brain tissues from diabetic mice exposed to acute or recurrent hypoglycemia.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary The brain is an important controller of glucose homeostasis and mediates counterregulatory responses to hypoglycemia. We used single-nuclei transcriptomics to study the mechanisms of defective hypoglycaemia counter-regulation in brain in a model of diabetic mice exposed to acute or recurrent hypoglycemia.
Overall design Single nuclei were isolated from hypothalamus and cortex tissues of diabetic mice subjected to recurrent (RH) or acute hypoglycemia (AH) and used to generate transcriptome profiles.
Contributor(s) Castillo Armengol J, Marzetta F, Rodriguez Sanchez-Archidona A, Thorens B
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Submission date Feb 28, 2023
Last update date Oct 03, 2023
Contact name Flavia Marzetta
Organization name Swiss Institute of Bioinformatics
Street address Quartier Sorge - Batiment Genopode
City Lausanne
ZIP/Postal code 1015
Country Switzerland
Platforms (2)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (14)
GSM7070456 Hypothalamus RH, replicate 1, Multiome (RNA)
GSM7070457 Hypothalamus AH, replicate 1, Multiome (RNA)
GSM7070458 Hypothalamus RH, replicate 2, Multiome (RNA)
BioProject PRJNA939516

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE226277_RAW.tar 6.3 Gb (http)(custom) TAR (of H5, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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