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| Status |
Public on Mar 17, 2023 |
| Title |
Cleavage Under Targets and Release Using Nuclease (CUT&RUN) assay of glucocorticoid receptor (NR3C1) in aggressive B-cell lymphomas [JC3] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We determined that glucocorticoid treatment (prednisolone) affects oncogenic signaling in aggressive B-cell lymphomas. We sought to identify genes directly controlled and bound by NR3C1.
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| Overall design |
CUT and RUN assay to NR3C1-bound regions in HBL1, SUDHL5, FL318, RAMOS cells treated with DMSO or prednisolone (10mM for HBL1, FL318, RAMOS or 25nm for SUDHL5) for 2h and 18h.
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| Contributor(s) |
Choi J, Staudt LM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 07, 2023 |
| Last update date |
Mar 19, 2023 |
| Contact name |
David Huang |
| Organization name |
National Cancer Institute
|
| Street address |
9000 Rockville Pike
|
| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20892-0001 |
| Country |
USA |
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| Platforms (1) |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
| GSE225858 |
Targeting oncogenic BCR signaling therapeutically by glucocorticoids and CSK inhibition |
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| Relations |
| BioProject |
PRJNA941917 |
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