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| Status |
Public on Mar 19, 2023 |
| Title |
Lipid engulfed macrophages interfere with protective T cell immunity and favor tumor progression in human colon carcinogenesis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Obesity and altered lipid metabolism is associated with colorectal cancer (CRC). In this context, the presence of colonic lipid-engulfed macrophages (foam cells, FC) may be involved in hindering protective T cell immunity, thus favoring gut carcinogenesis.
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| Overall design |
By analysing FC-enriched versus FC-deprived tissues of in precancerous intestinal lesions and stage I-II CRC, we investigated the function of dyslipidemic myeloid subsets with respect to antitumoral immunosurveillance.
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| Contributor(s) |
Daveri E, Ferrero G, Rivoltini L |
| Citation missing |
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| Submission date |
Mar 13, 2023 |
| Last update date |
Mar 20, 2023 |
| Contact name |
Giulio Ferrero |
| Organization name |
University of Turin
|
| Department |
Dept. Clinical and Biological Sciences
|
| Street address |
Regione Gonzole, 10
|
| City |
Orbassano |
| State/province |
TO |
| ZIP/Postal code |
10043 |
| Country |
Italy |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA944128 |
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