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Series GSE227357 Query DataSets for GSE227357
Status Public on Mar 19, 2023
Title Genome-wide mapping of NRF1 (NFE2L1) binding in HCT116 cells upon proteasome inhibition.
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The maintenance of protein homeostasis is an essential characteristic of life. Transcription factor NRF1 (NFE2L1) has been reported to be activated by proteasome dysfunction, although the genome-wide target genes are poorly understood. Using ChIP-seq analysis, we found a potential association between NRF1 and autophagy. Our findings highlight the new activation mechanism of autophagy through gene regulation under proteasome dysfunction.
 
Overall design Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for transcription factor NRF1 in HCT116 cells treated with 1 µM MG132 for 16 h.
 
Contributor(s) Hatanaka A, Watanabe A, Waku T, Kobayashi A
Citation(s) 37658135
Submission date Mar 14, 2023
Last update date Sep 15, 2023
Contact name Akira Kobayashi
E-mail(s) akobayas@mail.doshisha.ac.jp
Phone +81-774-65-6273
Organization name Doshisha University
Street address 1-3 Tatara Miyakodani
City Kyotanabe
ZIP/Postal code 610-0394
Country Japan
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (2)
GSM7098858 HCT116, NRF1
GSM7098859 HCT116, input
Relations
BioProject PRJNA944699

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE227357_RAW.tar 863.4 Mb (http)(custom) TAR (of BED, TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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