|
|
GEO help: Mouse over screen elements for information. |
|
Status |
Public on Mar 19, 2023 |
Title |
Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing Other
|
Summary |
Angiosarcomas are rare malignant tumors of the endothelium, arising commonly from the head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and human herpesvirus-7 (HHV-7) infection. We examined 81 cases of angiosarcomas, including 47 cases of AS-HN, integrating information from whole genome sequencing, gene expression profiling and spatial transcriptomics (10X Visium). In this dataset spatial transcriptomics revealed topological profiles of the tumor microenvironment, identifying dominant but tumor-excluded inflammatory signals in “immune-hot” cases and immune foci even in otherwise “cold” cases. In conclusion, spatial transcriptomics reveal the tumor immune landscape of angiosarcoma, and in combination with multi-omic information, may improve implementation of treatment strategies.
|
|
|
Overall design |
Spatial transcriptomics of 4 Asian Head and Neck Angiosarcoma 10X Genomics Visium
|
|
|
Contributor(s) |
Chan YJ, Loh JW, Lim AH |
Citation(s) |
37106027 |
Submission date |
Mar 16, 2023 |
Last update date |
May 03, 2023 |
Contact name |
Abner Lim |
E-mail(s) |
abner.lim.m.s@nccs.com.sg
|
Organization name |
National Cancer Center Singapore
|
Department |
Division of Medical Oncology
|
Lab |
Cancer Discovery Hub
|
Street address |
30 Hospital Boulevard
|
City |
Singapore |
ZIP/Postal code |
168583 |
Country |
Singapore |
|
|
Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
Samples (4)
|
|
Relations |
BioProject |
PRJNA945325 |
Supplementary file |
Size |
Download |
File type/resource |
GSE227469_RAW.tar |
568.8 Mb |
(http)(custom) |
TAR (of H5, MTX, PNG, TSV) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
|
|
|
|
|