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| Status |
Public on Mar 19, 2023 |
| Title |
Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
Angiosarcomas are rare malignant tumors of the endothelium, arising commonly from the head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and human herpesvirus-7 (HHV-7) infection. We examined 81 cases of angiosarcomas, including 47 cases of AS-HN, integrating information from whole genome sequencing, gene expression profiling and spatial transcriptomics (10X Visium). In this dataset spatial transcriptomics revealed topological profiles of the tumor microenvironment, identifying dominant but tumor-excluded inflammatory signals in “immune-hot” cases and immune foci even in otherwise “cold” cases. In conclusion, spatial transcriptomics reveal the tumor immune landscape of angiosarcoma, and in combination with multi-omic information, may improve implementation of treatment strategies.
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| Overall design |
Spatial transcriptomics of 4 Asian Head and Neck Angiosarcoma
10X Genomics Visium
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| Contributor(s) |
Chan YJ, Loh JW, Lim AH |
| Citation(s) |
37106027 |
| Submission date |
Mar 16, 2023 |
| Last update date |
May 03, 2023 |
| Contact name |
Abner Lim |
| E-mail(s) |
abner.lim.m.s@nccs.com.sg
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| Organization name |
National Cancer Center Singapore
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| Department |
Division of Medical Oncology
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| Lab |
Cancer Discovery Hub
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| Street address |
30 Hospital Boulevard
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| City |
Singapore |
| ZIP/Postal code |
168583 |
| Country |
Singapore |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA945325 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE227469_RAW.tar |
568.8 Mb |
(http)(custom) |
TAR (of H5, MTX, PNG, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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