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Series GSE22940 Query DataSets for GSE22940
Status Public on Jan 01, 2011
Title PFOS and PFHxS decrease lipoprotein production
Organism Mus musculus
Experiment type Expression profiling by array
Third-party reanalysis
Summary The effect of perfluoroalkyl sulfonates on lipoprotein metabolism was investigated in APOE*3-Leiden.CETP mice with a humanized lipoprotein profile. Perfluorohexane sulfonate and perfluorooctane sulfonate markedly reduced both plasma TG and TC by decreasing nonHDL-C and HDL-C accompanied by a reduction in apoAI. Mechanistic studies showed that these effects were mainly caused by impaired lipoprotein production.
Overall design Male E3L.CETP mice on a C57Bl/6 background were fed a Western-type diet, containing 0.25% (w/w) cholesterol, 1% (w/w) corn oil and 14% (w/w) bovine fat (Western-type diet) (Hope Farms, Woerden, The Netherlands) for 4 to 6 weeks in three independent experiments. Upon randomization according to total plasma cholesterol (TC) and TG levels, mice received the Western-type diet without or with PFBS (30 mg/kg/day), PFHxS (6 mg/kg/day) or PFOS (3 mg/kg/day) during 4-6 weeks. The effects of these PFAS on plasma lipids and lipoproteins were determined. In addition, PFAS levels were determined in plasma and livers were isolated for hepatic lipid analysis and hepatic gene expression analysis using an Affymetrix technology platform and Affymetrix GeneChip® mouse genome 430 2.0 arrays.
Contributor(s) Bijland S, Rensen PC, Pieterman EJ, Maas AC, van der Hoorn JW, van Erk MJ, Havekes LM, Willems van Dijk K, Chang S, Ehresman DJ, Butenhoff JL, Princen HM
Citation(s) 21705711
Submission date Jul 14, 2010
Last update date Jan 17, 2013
Contact name MJ van Erk
Organization name TNO Quality of Life
Street address PO Box 360
City Zeist
ZIP/Postal code 3700AJ
Country Netherlands
Platforms (1)
GPL10288 Affymetrix GeneChip Mouse Genome 430 2.0 Array [CDF: Mm_ENTREZG_11]
Samples (18)
GSM566443 PFBS_1
GSM566444 PFBS_2
GSM566445 PFBS_3
Affiliated with GSM530347
Affiliated with GSM530348
Affiliated with GSM530349
Affiliated with GSM530350
Affiliated with GSM530351
Affiliated with GSM530352
Affiliated with GSM530353
Affiliated with GSM530354
Affiliated with GSM530355
Affiliated with GSM530356
Affiliated with GSM530357
Affiliated with GSM530358
BioProject PRJNA127779

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22940_RAW.tar 68.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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