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Series GSE230112 Query DataSets for GSE230112
Status Public on Apr 12, 2024
Title Histone H3K27 methyltransferase EZH2 interacts with MEG3-lncRNA to directly regulate integrin signaling and endothelial cell function
Organism Homo sapiens
Experiment type Other
Summary We profiled EZH2-RNA interactions using formaldehyde/UV assisted cross-linking ligation and sequencing of hybrids (FLASH-seq) in primary human ECs. Transcriptome-wide EZH2-associated ncRNAs and RNA–RNA interactome were obtained.
Overall design Nine different FLASH experiments were carried out on human HUVEC cells, with EZH2 or an IgG control used as bait proteins.
Contributor(s) Dudnakova T, Dunn-Davies H, Nogara A, Rodor J, Thomas A, Parish E, Gautier P, Meynert A, Madeddu P, Caporali A, Baker A, Tollervey D, Mitic T
Citation(s) 38617973
Submission date Apr 20, 2023
Last update date May 01, 2024
Contact name Hywel Dunn-Davies
Organization name University of Edinburgh
Department Wellcome Trust Centre for Cell Biology
Lab Tollervey Lab
Street address Max Born Crescent
City Edinburgh
ZIP/Postal code EH9 3BF
Country United Kingdom
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (9)
GSM7187730 191227_Lec_L5Ba_IgG1
GSM7187731 191227_Lec_L5Bc_EZH2 (1)
GSM7187732 191227_Lec_L5Db_IgG2
BioProject PRJNA957616

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Supplementary file Size Download File type/resource
GSE230112_RAW.tar 72.8 Mb (http)(custom) TAR (of BED, TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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