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Series GSE230139 Query DataSets for GSE230139
Status Public on Dec 01, 2023
Title Diet supplemented with polyphenol- and glucuronoxylan-rich fiber extract regulates colonic barrier function and cell proliferation in healthy rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary A diet rich in dietary fiber and polyphenols supports the normal intestinal barrier function crucial for intestinal and overall health. Birch wood-derived fiber containing glucuronoxylans (GX)- and polyphenols have the potential in multiple food technological applications and have favorable effects on gut microbiota and colonic metabolism. However, their impact on intestinal barrier function is unknown. To elucidate their potential as new intestinal health-supporting food ingredients, we investigated the effect of GX- and polyphenol-rich extract (GXpoly ) and highly purified GX-rich extract (pureGX) on the gene expression of the colon mucosa.
Overall design Four-week-old female and male Wistar rats were acclimatized for 12 days and then fed diets supplemented with 10% w/w of polyphenol-and glucoronoxylan-rich extract (GXpoly), highly purified glucoronoxylan (pureGX), or cellulose (control) for four weeks. Gene expression of the mucosa of the colon mid-segment was investigated using Agilent gene expression microarrays with a two-colour design. Samples were carefully randomized for the microarray experiment to control batch effects arising from the experimental set up. Each experimental group contains samples from 10-11 rats (both male and female).
Please note that each raw data file contains raw data for two samples as indicated in the corresponding sample description field and thus is linked to the Series records.
Contributor(s) Kynkäänniemi E, Linden J, Ngambundit S, Saarimäki LA, Greco D, Slaba H, Lahtinen M, Mikkonen KS, Pajari A
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Submission date Apr 20, 2023
Last update date Dec 01, 2023
Contact name Dario Greco
Organization name Tampere University
Department Faculty of Medicine and Health Technology
Lab Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE)
Street address Arvo ylpön Katu 34
City Tampere
ZIP/Postal code 33520
Country Finland
Platforms (1)
GPL22145 Agilent-074036 SurePrint G3 Rat GE v2 8x60K Microarray G4858A (Feature Number version)
Samples (32)
GSM7188081 control_1
GSM7188082 GXpoly_1
GSM7188083 pureGX_1
BioProject PRJNA957722

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE230139_RAW.tar 10.4 Mb (http)(custom) TAR
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_1_1.txt.gz 6.1 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_1_2.txt.gz 6.1 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_1_3.txt.gz 6.2 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_1_4.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_2_1.txt.gz 6.1 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_2_2.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_2_3.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611527_S01_GE2_1200_Jun14_2_4.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_1_1.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_1_2.txt.gz 6.1 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_1_3.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_1_4.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_2_1.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_2_2.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_2_3.txt.gz 6.0 Mb (ftp)(http) TXT
GSE230139_US11263921_257403611528_S01_GE2_1200_Jun14_2_4.txt.gz 6.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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