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Series GSE230568 Query DataSets for GSE230568
Status Public on Apr 30, 2023
Title Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis [scData]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Other
Summary Primary sclerosing cholangitis (PSC) is an autoimmune-like disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with both PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single cell transcriptomics, and T- and B-cell receptor repertoire analysis of right colon tissue from PSC, IBD, and healthy controls we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia specifically in patients with PSC. This inflammatory signature is characterized by antigen-driven IL-17A+ Foxp3+ CD4 T-cell and an expansion of IgG-secreting B-cell responses. These data results suggest that the mechanisms that drive the emergence of dysplasia in of PSC and IBD dysplasia are distinct and provide molecular insights to guide prevention of colorectal cancer in PSC.
 
Overall design Colon biopsy gene expression profiles from PSC
 
Contributor(s) Shaw DG
Citation(s) 37322120
Submission date Apr 25, 2023
Last update date Sep 08, 2023
Contact name Luis B Barreiro
E-mail(s) barreirolabchicago@gmail.com
Organization name University of Chicago
Lab Barreiro Lab
Street address 900 E 57th Street
City Chicago
ZIP/Postal code 60637
Country USA
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (27)
GSM7226818 PSC15E-scBCR
GSM7226819 PSC19D-scBCR
GSM7226820 PSC28D-scBCR
This SubSeries is part of SuperSeries:
GSE230569 Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis
Relations
BioProject PRJNA961775

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Supplementary file Size Download File type/resource
GSE230568_RAW.tar 33.6 Mb (http)(custom) TAR (of CSV, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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