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Status |
Public on Jun 10, 2023 |
Title |
Y chromosome loss in bladder cancer contributes to T cell exhaustion and sensitivity to immune checkpoint blockade [WES] |
Organism |
Mus musculus |
Experiment type |
Other
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Summary |
Loss of the Y chromosome (LOY) is observed in several common cancer types, including 10-40% of bladder cancers, but the clinical and biological significance of this finding is unknown. Through genomic and transcriptomic studies, we report that low LOY gene signature scores correlate with poor prognoses in patients with bladder cancer. We then performed in-depth studies of natural occurring bladder cancer cells with LOY mutants as well as those with targeted deletion of Y chromosome by CRISPR/Cas9. Both Y+ and Y- tumors had similar growth kinetics in vitro, while Y- tumors grew faster than Y+ tumors in immune competent hosts in a T cell-dependent manner
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Overall design |
Whole Exome sequencing for MB49 parental , MB49 Y chromosome positive and MB49 Y chromosome negative cell lines.
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Contributor(s) |
Abdel-Hafiz HA, Schafer JM, Li Z, Theodorescu D |
Citation(s) |
37344596 |
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Submission date |
Apr 27, 2023 |
Last update date |
Apr 05, 2024 |
Contact name |
Hany A Abdel-Hafiz |
E-mail(s) |
hany.abdel-hafiz@cshs.org
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Organization name |
Cedars-Sinai Medical Center
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Department |
Medicine/ Medical Oncology
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Street address |
110 N George Burns RD, DRoom 3057
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City |
los Angeles |
State/province |
California |
ZIP/Postal code |
90036 |
Country |
USA |
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Platforms (1) |
GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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Samples (3) |
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This SubSeries is part of SuperSeries: |
GSE230820 |
Y chromosome loss in cancer drives growth by evasion of adaptive immunity |
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Relations |
BioProject |
PRJNA962610 |