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Series GSE230819 Query DataSets for GSE230819
Status Public on Jun 10, 2023
Title Y chromosome loss in bladder cancer contributes to T cell exhaustion and sensitivity to immune checkpoint blockade [WES]
Organism Mus musculus
Experiment type Other
Summary Loss of the Y chromosome (LOY) is observed in several common cancer types, including 10-40% of bladder cancers, but the clinical and biological significance of this finding is unknown. Through genomic and transcriptomic studies, we report that low LOY gene signature scores correlate with poor prognoses in patients with bladder cancer. We then performed in-depth studies of natural occurring bladder cancer cells with LOY mutants as well as those with targeted deletion of Y chromosome by CRISPR/Cas9. Both Y+ and Y- tumors had similar growth kinetics in vitro, while Y- tumors grew faster than Y+ tumors in immune competent hosts in a T cell-dependent manner
Overall design Whole Exome sequencing for MB49 parental , MB49 Y chromosome positive and MB49 Y chromosome negative cell lines.
Contributor(s) Abdel-Hafiz HA, Schafer JM, Li Z, Theodorescu D
Citation(s) 37344596
Submission date Apr 27, 2023
Last update date Apr 05, 2024
Contact name Hany A Abdel-Hafiz
Organization name Cedars-Sinai Medical Center
Department Medicine/ Medical Oncology
Street address 110 N George Burns RD, DRoom 3057
City los Angeles
State/province California
ZIP/Postal code 90036
Country USA
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (3)
GSM7243458 MB49 parental cell line
GSM7243459 Y CHROMOSOME positive cell line
This SubSeries is part of SuperSeries:
GSE230820 Y chromosome loss in cancer drives growth by evasion of adaptive immunity
BioProject PRJNA962610

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE230819_RAW.tar 1.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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