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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 10, 2024 |
| Title |
Multifunctional Enzyme Nanocapsules Boost T Cell Immunity and Multifunctional Enzyme Nanocapsules Boost T Cell Immunity and Efficacy of Cancer Immunotherapy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cancer immunotherapy has reshaped the landscape of cancer treatment, but its effectiveness is limited by tumor immunosuppression caused by excessive lactate production by cancer cells. While efforts to reduce lactate levels through lactate dehydrogenase inhibition have been made, such inhibitors can disrupt the metabolism of healthy cells and cause severe non-specific toxicity. Based on lactate oxidase, we report herein an enzyme therapeutic, which reduces lactate levels, releases an immunostimulatory molecule-hydrogen peroxide, averts tumor immunosuppression, and synergistically improves the efficacy of immune checkpoint blockades, as demonstrated in a murine melanoma model and a humanized mouse model of triple-negative breast cancer.
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| Overall design |
Single-cell RNA seq of tumor cells treated with and without nanoparticles
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| Contributor(s) |
Wen J, Cao Z, Harding J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 28, 2023 |
| Last update date |
May 10, 2024 |
| Contact name |
Jeffrey Harding |
| E-mail(s) |
jharding@mednet.ucla.edu
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| Organization name |
University of California Los Angeles
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| Street address |
405 Hilgard Avenue
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (4)
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| GSM7246663 |
Nanocapsule treated, replicate 2, scRNAseq |
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| Relations |
| BioProject |
PRJNA962913 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE230896_RAW.tar |
336.9 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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