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Status |
Public on May 03, 2024 |
Title |
Employment of exosome-mimetic nanovesicles as a plasma adjuvant for cancer targeting through Golgi stress-associated ferroptosis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Plasma oncology is a promising therapeutic method that employs ionized gas to selectively target cancer cells. However, despite its efficacy in directly exposing external cancer cells to plasma, a stable delivery method through the circulatory system to internal cancer cells has yet to be developed. In this study, we revealed that bioinspired exosome-mimetic nanovesicles (EMs) can serve as a plasma adjuvant to enhance the anti-cancer effect. EM treatment increased the half-life of plasma reactive species such as nitrogen oxide in solution, thereby increasing the cytotoxicity towards cancer cells. Our syngeneic mice model experiment demonstrated that EM-treated plasma (EM-Plasma) inhibited in vivo cancer growth more efficiently than conventional plasma administration. Furthermore, we uncovered a molecular mechanism through which EM-Plasma selectively induces cancer cell death, namely, Golgi stress-associated ferroptosis. Our study provides a promising approach for the clinical application of plasma oncology in cancer treatment.
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Overall design |
Transcriptomic profiles of B16 melanoma cells with or without EM-Plasma treatment.
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Contributor(s) |
Bin B, Kwak B, Chae S, Heo H, Brito S, Cha B |
Citation missing |
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Submission date |
May 03, 2023 |
Last update date |
May 03, 2024 |
Contact name |
Sehyun Chae |
E-mail(s) |
shchae@kbri.re.kr
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Organization name |
Korea Brain Research Institute
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Department |
Neurovascular Unit Research Group
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Street address |
61, Cheomdan-ro, Dong-gu
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City |
Daegu |
ZIP/Postal code |
41062 |
Country |
South Korea |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (4)
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Relations |
BioProject |
PRJNA966970 |