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Series GSE231561 Query DataSets for GSE231561
Status Public on May 03, 2024
Title Employment of exosome-mimetic nanovesicles as a plasma adjuvant for cancer targeting through Golgi stress-associated ferroptosis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Plasma oncology is a promising therapeutic method that employs ionized gas to selectively target cancer cells. However, despite its efficacy in directly exposing external cancer cells to plasma, a stable delivery method through the circulatory system to internal cancer cells has yet to be developed. In this study, we revealed that bioinspired exosome-mimetic nanovesicles (EMs) can serve as a plasma adjuvant to enhance the anti-cancer effect. EM treatment increased the half-life of plasma reactive species such as nitrogen oxide in solution, thereby increasing the cytotoxicity towards cancer cells. Our syngeneic mice model experiment demonstrated that EM-treated plasma (EM-Plasma) inhibited in vivo cancer growth more efficiently than conventional plasma administration. Furthermore, we uncovered a molecular mechanism through which EM-Plasma selectively induces cancer cell death, namely, Golgi stress-associated ferroptosis. Our study provides a promising approach for the clinical application of plasma oncology in cancer treatment.
Overall design Transcriptomic profiles of B16 melanoma cells with or without EM-Plasma treatment.
Contributor(s) Bin B, Kwak B, Chae S, Heo H, Brito S, Cha B
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Submission date May 03, 2023
Last update date May 03, 2024
Contact name Sehyun Chae
Organization name Korea Brain Research Institute
Department Neurovascular Unit Research Group
Street address 61, Cheomdan-ro, Dong-gu
City Daegu
ZIP/Postal code 41062
Country South Korea
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7290801 Control_1
GSM7290802 Control_2
GSM7290803 Plasma_treat4h_1
BioProject PRJNA966970

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE231561_RAW.tar 960.0 Kb (http)(custom) TAR (of TXT)
GSE231561_Raw_counts_matrix.txt.gz 299.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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