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Series GSE232128 Query DataSets for GSE232128
Status Public on Oct 03, 2023
Title Green tea polyphenols alleviate liver injury induced by di(2-ethylhexyl) phthalate in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Di (2-ethylhexyl) phthalate (DEHP) is a common plasticizer. Studies have revealed that DEHP exposure can cause liver damage. Green tea is one of the most popular beverages in China. Green tea polyphenols (GTPs) have been proven to have therapeutic effects on organ damage induced by heavy metal exposure. However, few study report on GTP relieving DEHP-induced liver damage.
Overall design C57BL/6J mice were treated with distilled water (control group), 1500 mg/kg/d DEHP + corn oil (model group), 1500 mg/kg/d DEHP + corn oil + 70 mg/kg GTP (treatment group), corn oil (oil group), and 70 mg/kg GTP (GTP group) by gavage for 8 weeks, respectively. The hepatic tissues histopathology of each group were measured. The hepatic tissues of mice in the model, treatment, and control groups were analyzed using high-throughput sequencing.
Contributor(s) Shi H, Sun S, Zhu S
Citation(s) 37753369
Submission date May 10, 2023
Last update date Oct 03, 2023
Contact name Shengyun Sun
Organization name The First Affiliated Hospital of Jinan University
Street address 613 West Huangpu Avenue
City Guangzhou
State/province Guangdong
ZIP/Postal code 522000
Country China
Platforms (1)
GPL23479 BGISEQ-500 (Mus musculus)
Samples (9)
GSM7315662 Liver, Control_1
GSM7315663 Liver, Control_2
GSM7315664 Liver, Control_3
BioProject PRJNA971094

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE232128_processed_data.xlsx 928.7 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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