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| Status |
Public on Dec 01, 2023 |
| Title |
Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma [4NQOinDBLgata] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Eosinophils are present in several solid tumors and have context-dependent function. The role of eosinophils in the development of esophageal squamous cell cancer (ESCC), 85% of esophageal cancers worldwide, is unknown. Mice were treated with 4-nitroquinolone-1-oxide (4-NQO) for 8 weeks followed by vehicle for 8 weeks to induce esophageal squamous pre-cancer. Eosinophil depletion using three mouse models resulted in exacerbated 4-NQO tumorigenesis. RNA-sequencing on the whole esophagus of WT and ?dblGATA mice was done in the pre-cancer model to understand how the presence of eosinophils affects the pre-cancer esophageal environment.
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| Overall design |
We performed RNA-sequencing on the whole esophagus of C57/BL6 WT and DdblGATA mice after treatment with 4-NQO for 8 weeks followed by propylene glycol vehicle for 8 weeks resulting in pre-cancer.
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| Web link |
https://www.cmghjournal.org/article/S2352-345X(23)00149-2/fulltext
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| |
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| Contributor(s) |
Jacobse J, Choksi YA |
| Citation(s) |
37574015 |
| |
| Submission date |
May 25, 2023 |
| Last update date |
Dec 01, 2023 |
| Contact name |
Justin Jacobse |
| Organization name |
Vanderbilt University Medical Center
|
| Street address |
2215 Garland Avenue
|
| City |
Nashville |
| State/province |
Tennessee |
| ZIP/Postal code |
37232 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (13)
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| GSM7428163 |
Esophagus, WT4 |
| GSM7428164 |
Esophagus, WT5 |
| GSM7428165 |
Esophagus, WT6 |
| GSM7428166 |
Esophagus, KO1 |
| GSM7428167 |
Esophagus, KO2 |
| GSM7428168 |
Esophagus, KO3 |
| GSM7428169 |
Esophagus, KO4 |
| GSM7428170 |
Esophagus, KO5 |
| GSM7428171 |
Esophagus, KO6 |
| GSM7428172 |
Esophagus, KO7 |
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| This SubSeries is part of SuperSeries: |
| GSE233668 |
Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma |
|
| Relations |
| BioProject |
PRJNA976278 |
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