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Series GSE23347 Query DataSets for GSE23347
Status Public on Feb 08, 2011
Title Gene Expression Profiling In Murine Corneal Neovascularization Models
Organism Mus musculus
Experiment type Expression profiling by array
Summary In order to find out the vital genes during the corneal neovascularization (CNV), we set up two CNV models, one being induced by suture placement and the other by alkali burn to the corneal center. Young adult Balb/c and C57BL/6 were used. The corneas were checked daily for CNV development and some of the corneas were removed at two pre-determined time points for RNA extraction. Preliminary experiment indicated slightly different dynamics in suture- or chemical burn-induced CNV. Vigorous growth appeared at day 5 and day 6 in S-CNV and CB-CNV, and reached maximum length around day 10 and day 14, respectively, in S-CNV and CB-CNV. To check whether genetic MHC background has any effect on development of CNV, we compared CB-CNV in Balb/c and C57BL/6 mice at day 6.
Overall design Corneas from Balb/c mice were isolated 5 and 10 days after suture-induced CNV, and 6 and 14 days after chemical burn-induced CNV. Corneas from C57BL/6 mice were isolated 6 days after chemical burn-induced CNV. Each time point had two or three biological replications.
Contributor(s) Wang Y, Wang C, Jia C, Ren S, Yang L
Citation(s) 20596249, 21139687, 21921991, 28847716, 24790856
Submission date Jul 30, 2010
Last update date Aug 22, 2019
Contact name Yiqiang Wang
Phone 86-512-67780780
Organization name Xiamen University
Street address 2000 East Xiangan Road
City Xiamen
ZIP/Postal code 361101
Country China
Platforms (1)
GPL10745 CapitalBio 36K Mouse Genome Array
Samples (12)
GSM572955 Suture-induced CNV After Injury 5 Day, Replication 1
GSM572956 Suture-induced CNV After Injury 5 Day, Replication 2
GSM572957 Suture-induced CNV After Injury 5 Day, Replication 3
BioProject PRJNA131455

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Supplementary file Size Download File type/resource
GSE23347_RAW.tar 26.9 Mb (http)(custom) TAR (of LSR)
Processed data included within Sample table

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