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| Status |
Public on Jun 07, 2023 |
| Title |
Efficacy of antiviral therapy and host-virus interactions visualized using serial liver sampling with fine-needle aspirates |
| Organism |
Hepatitis B virus |
| Experiment type |
Other
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| Summary |
Infection-dependent transcriptional changes and the impact of antiviral therapy on viral replication can be measured in longitudinal human liver biopsies using single-cell RNA sequencing data
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| Overall design |
Investigator-initiated, phase 4 study in which recruited patients received TAF 25mg once daily for 48 weeks. The total duration of the study to End of Follow-up was 48 weeks. After Week 48, participants were offered 2 years of TAF therapy. Sample collection 0, 12, 24 w was chosen to analyze immune responses based on ALT normalization rates. This mono-center study was conducted at Toronto Centre for Liver Disease, Canada.
>>>Raw data for human samples not available due to patient privacy concerns<<<
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| Contributor(s) |
Kim SC, Wallin JJ, Ghosheh Y, Zahoor MA, Sanchez Vasquez JD, Nkongolo S, Fung S, Mendez P, Feld JJ, Janssen HL, Gehring AJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 02, 2023 |
| Last update date |
Jun 09, 2023 |
| Contact name |
Adam Gehring |
| E-mail(s) |
adam.gehring@uhnresearch.ca
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| Organization name |
UHN
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| Street address |
101 College St
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| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
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| Platforms (1) |
| GPL32478 |
Illumina HiSeq 2500 (Hepatitis B virus) |
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| Samples (12)
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| GSM7441025 |
liver, patient8, week12 |
| GSM7441026 |
liver, patient8, week24 |
| GSM7441027 |
liver, patient9, week0 |
| GSM7441028 |
liver, patient9, week24 |
| GSM7441029 |
liver, patient10, week0 |
| GSM7441030 |
liver, patient10, week12 |
| GSM7441031 |
liver, patient11, week0 |
| GSM7441032 |
liver, patient11, week12 |
| GSM7441033 |
liver, patient11, week24 |
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| Relations |
| BioProject |
PRJNA979188 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234015_RAW.tar |
3.9 Mb |
(http)(custom) |
TAR (of BAM, TSV) |
| Raw data not provided for this record |
| Processed data provided as supplementary file |
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