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Series GSE234015 Query DataSets for GSE234015
Status Public on Jun 07, 2023
Title Efficacy of antiviral therapy and host-virus interactions visualized using serial liver sampling with fine-needle aspirates
Organism Hepatitis B virus
Experiment type Other
Summary Infection-dependent transcriptional changes and the impact of antiviral therapy on viral replication can be measured in longitudinal human liver biopsies using single-cell RNA sequencing data
Overall design Investigator-initiated, phase 4 study in which recruited patients received TAF 25mg once daily for 48 weeks. The total duration of the study to End of Follow-up was 48 weeks. After Week 48, participants were offered 2 years of TAF therapy. Sample collection 0, 12, 24 w was chosen to analyze immune responses based on ALT normalization rates. This mono-center study was conducted at Toronto Centre for Liver Disease, Canada.
>>>Raw data for human samples not available due to patient privacy concerns<<<
Contributor(s) Kim SC, Wallin JJ, Ghosheh Y, Zahoor MA, Sanchez Vasquez JD, Nkongolo S, Fung S, Mendez P, Feld JJ, Janssen HL, Gehring AJ
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Submission date Jun 02, 2023
Last update date Jun 09, 2023
Contact name Adam Gehring
Organization name UHN
Street address 101 College St
City Toronto
State/province ON
ZIP/Postal code M5G 1L7
Country Canada
Platforms (1)
GPL32478 Illumina HiSeq 2500 (Hepatitis B virus)
Samples (12)
GSM7441022 liver, patient4, week0
GSM7441023 liver, patient4, week24
GSM7441024 liver, patient8, week0
BioProject PRJNA979188

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE234015_RAW.tar 3.9 Mb (http)(custom) TAR (of BAM, TSV)
Raw data not provided for this record
Processed data provided as supplementary file

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