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Series GSE234043 Query DataSets for GSE234043
Status Public on Jun 07, 2023
Title Transcriptional chracterization of ABCC1 and ABCB1 KO and MZ1 treated WT HAP1 cell lines.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We used CRISPR/Cas9 to intoroduce frame-shifting mutations into the ABCC1 and ABCB1 genes and treated HAP1 WT cells with varying concentrations of the MZ1 PROTAC. To measure the transcriptional response to both genetic and chemical perturbances, we performed RNA-seq and quantified gene expression levels.
Overall design 6 cell lines, untreated or MZ1 treated in 1-3 technical replicates
Contributor(s) Wolf G, Onstein S, Christodoulaki E, Superti-Furga G
Citation(s) 37516113
Submission date Jun 02, 2023
Last update date Sep 14, 2023
Contact name Gernot Ernst Josef Wolf
Organization name CeMM
Street address Lazarettgasse 14
City Vienna
ZIP/Postal code 1090
Country Austria
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (20)
GSM7441674 HAP1-Cas9-p2A-Blast-c3_rep1
GSM7441675 HAP1-Cas9-p2A-Blast-c3_rep2
GSM7441676 HAP1_WT_rep1
BioProject PRJNA979232

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Supplementary file Size Download File type/resource
GSE234043_count_table.tsv.gz 886.7 Kb (ftp)(http) TSV
GSE234043_tpm_table.tsv.gz 1.1 Mb (ftp)(http) TSV
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