|
| Status |
Public on Jun 30, 2023 |
| Title |
Genome wide CRISPR screen in AML chemotherapy resistance. |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
Chemoresistance is the leading cause of acute myeloid leukemia (AML)-related deaths, and elucidation of the mechanisms of AML chemoresistance is necessary to effectively target this process. Here, we performed genome wide CRISPR-Cas9 screening to identify key molecules regulating AML chemoresistance.
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| |
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| Overall design |
sgRNA counts from THP-1 hCas9 cells infected with two lentiviral gRNA libraries challenged with IDA treatment (1.5 ng/mL) or kept in regular medium.
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| |
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| Contributor(s) |
Meng G, Sun T, Li M, Ji C |
| Citation(s) |
37469404 |
| |
| Submission date |
Jun 23, 2023 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Chunyan Ji |
| Organization name |
Qilu Hospital
|
| Street address |
Wenhua West Road
|
| City |
Jinan |
| ZIP/Postal code |
250000 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA986910 |
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