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Series GSE235688 Query DataSets for GSE235688
Status Public on Jun 30, 2023
Title Genome wide CRISPR screen in AML chemotherapy resistance.
Organism Homo sapiens
Experiment type Other
Summary Chemoresistance is the leading cause of acute myeloid leukemia (AML)-related deaths, and elucidation of the mechanisms of AML chemoresistance is necessary to effectively target this process. Here, we performed genome wide CRISPR-Cas9 screening to identify key molecules regulating AML chemoresistance.
Overall design sgRNA counts from THP-1 hCas9 cells infected with two lentiviral gRNA libraries challenged with IDA treatment (1.5 ng/mL) or kept in regular medium.
Contributor(s) Meng G, Sun T, Li M, Ji C
Citation(s) 37469404
Submission date Jun 23, 2023
Last update date Sep 12, 2023
Contact name Chunyan Ji
Organization name Qilu Hospital
Street address Wenhua West Road
City Jinan
ZIP/Postal code 250000
Country China
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (4)
GSM7507912 THP-1-libA T0
GSM7507913 THP-1-libB T0
GSM7507914 THP-1-libA T7 Control
BioProject PRJNA986910

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Supplementary file Size Download File type/resource 6.3 Mb (ftp)(http) ZIP
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