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| Status |
Public on Apr 03, 2024 |
| Title |
Lupus dermal fibroblasts hyper-respond to inflammatory cytokines and exhibit a pro-fibrotic phenotype to TGF-β in patients with scarring skin disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
we examined responses to cytokines in dermal fibroblasts from the skin of SLE patients with CLE and healthy control volunteers to identify the inflammatory phenotype and gene expression profile associated with SLE and scarring CLE lesions.
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| |
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| Overall design |
we first compared the inflammatory phenotype in fibroblasts isolated from healthy controls (HC) and from non-lesional skin of SLE patients with CLE to explore differences in gene expression that occur in the disease
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| Contributor(s) |
Kahlenberg JM, Shoffner-Beck SK, Abernathy-Close L, Gudjonsson JE, Tsoi LC |
| Citation(s) |
38358820 |
| |
| Submission date |
Jul 18, 2023 |
| Last update date |
Apr 03, 2024 |
| Contact name |
Lam Tsoi |
| E-mail(s) |
alextsoi@umich.edu
|
| Organization name |
University of Michigan
|
| Street address |
Medical Sciences 1 Bldg. 1301 E. Catherine
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (317)
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| Relations |
| BioProject |
PRJNA996167 |
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