GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE241951 Query DataSets for GSE241951
Status Public on Sep 04, 2023
Title olfactory bulb from control mouse and a mouse with developmentally-induced olfactory bulb degeneration
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The olfactory bulb (OB) is a critical component of mammalian olfactory neuroanatomy. Beyond being the first and sole relay station for olfactory information to the rest of the brain, it also contains elaborate stereotypical circuitry that is considered essential for olfaction. Indeed, substantial lesions of the OB in rodents lead to anosmia. Here, we examined the circuitry that underlies olfaction in a mouse model with severe developmental degeneration of the OB. These mice could perform odor-guided tasks and even responded normally to innate olfactory cues. Despite the near total loss of the OB, piriform cortex in these mice responded to odors normally and its neural activity sufficed to decode odor identity. We found that sensory neurons expressthe full repertoire of olfactory receptors and their axons project primarily to the rudiments of the OB, but also ectopically, to olfactory cortical regions. Within the OB, the number of principal neurons was greatly reduced and the morphology of their dendrites was abnormal, extending over large regions within the OB. Glomerular organization was totally lost in the severe cases of OB degeneration and altered in the more conserved OBs, and the transcriptional profile of the glomerular layer was highly inflammatory. This study shows that olfactory functionality can be preserved despite reduced and aberrant circuitry that is missing many of the elements that are believed to be essential for olfaction, and may explain reported retention of olfaction in humans with degenerated OBs
Overall design olfactory bulb from control mouse and a mouse with degenerated (28%) of the olfactory bulb
Web link
Contributor(s) Licht T, Rokni D, Shiff I
Citation(s) 37858342
Submission date Aug 30, 2023
Last update date Oct 22, 2023
Contact name Tamar Licht
Phone 972544703220
Organization name Hebrew University
Department Medical Neurobiology
Street address Hadassah ein karem
City Jerusalem
ZIP/Postal code 93211
Country Israel
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7746357 two serial sections of control OB (same mouse as C2)
GSM7746358 one slice of control olfactory bulb (same mouse as C1)
GSM7746359 two serial sections of mutant OB (same mouse as M2)
BioProject PRJNA1010800

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE241951_barcodes.tsv.gz 27.1 Kb (ftp)(http) TSV
GSE241951_features.tsv.gz 284.1 Kb (ftp)(http) TSV
GSE241951_images.tar.gz 1.2 Gb (ftp)(http) TAR
GSE241951_matrix.mtx.gz 57.3 Mb (ftp)(http) MTX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap