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| Status |
Public on Sep 04, 2023 |
| Title |
olfactory bulb from control mouse and a mouse with developmentally-induced olfactory bulb degeneration |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The olfactory bulb (OB) is a critical component of mammalian olfactory neuroanatomy. Beyond being the first and sole relay station for olfactory information to the rest of the brain, it also contains elaborate stereotypical circuitry that is considered essential for olfaction. Indeed, substantial lesions of the OB in rodents lead to anosmia. Here, we examined the circuitry that underlies olfaction in a mouse model with severe developmental degeneration of the OB. These mice could perform odor-guided tasks and even responded normally to innate olfactory cues. Despite the near total loss of the OB, piriform cortex in these mice responded to odors normally and its neural activity sufficed to decode odor identity. We found that sensory neurons expressthe full repertoire of olfactory receptors and their axons project primarily to the rudiments of the OB, but also ectopically, to olfactory cortical regions. Within the OB, the number of principal neurons was greatly reduced and the morphology of their dendrites was abnormal, extending over large regions within the OB. Glomerular organization was totally lost in the severe cases of OB degeneration and altered in the more conserved OBs, and the transcriptional profile of the glomerular layer was highly inflammatory. This study shows that olfactory functionality can be preserved despite reduced and aberrant circuitry that is missing many of the elements that are believed to be essential for olfaction, and may explain reported retention of olfaction in humans with degenerated OBs
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| |
|
| Overall design |
olfactory bulb from control mouse and a mouse with degenerated (28%) of the olfactory bulb
|
| Web link |
https://www.cell.com/current-biology/fulltext/S0960-9822(23)01310-6
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| |
|
| Contributor(s) |
Licht T, Rokni D, Shiff I |
| Citation(s) |
37858342 |
| |
| Submission date |
Aug 30, 2023 |
| Last update date |
Oct 22, 2023 |
| Contact name |
Tamar Licht |
| E-mail(s) |
Tamarli@ekmd.huji.ac.il
|
| Phone |
972544703220
|
| Organization name |
Hebrew University
|
| Department |
Medical Neurobiology
|
| Street address |
Hadassah ein karem
|
| City |
Jerusalem |
| ZIP/Postal code |
93211 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (4)
|
| GSM7746357 |
two serial sections of control OB (same mouse as C2) |
| GSM7746358 |
one slice of control olfactory bulb (same mouse as C1) |
| GSM7746359 |
two serial sections of mutant OB (same mouse as M2) |
| GSM7746360 |
two serial section of mutant olfactory bulb (same mouse as M1) |
|
| Relations |
| BioProject |
PRJNA1010800 |
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